PHENOTYPIC CHARACTERIZATION OF ANDROGEN RECEPTOR-RELATED PROLIFERATION IN PROSTATIC-CARCINOMA DERIVED CELL-CULTURES
- T ZWERGEL
- U BURK
- S HERTER
- T LINDENMEIR
- B WULLICH
- G UNTEREGGER
Affiliations: UNIV SAARLAND,DEPT HUMAN GENET,D-66421 HOMBURG,GERMANY.
- Published online on: December 1, 1995 https://doi.org/10.3892/ijo.7.6.1339
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Our study reviews the central role of androgens for the development of androgen-insensitive growth in prostatic carcinoma using an individual dynamic model which emulates aspects of proliferation control. Our aim is the identification of individually proliferating cells from prostate carcinoma. Short-term cultured cells (n=205) from radical prostatectomy specimens have been used as the major method to skew the correspondence between the androgen-receptor (AR), proliferation-markers (Ki-67, PCNA) and morphological landmarks (nucleoli, AgNOR). These techniques allowed the identification of distinct androgen-insensitive, proliferating cell-clusters and in the future will allow the analysis of genotypic changes in identified proliferating cell clones.