PHENOTYPIC CHARACTERIZATION OF ANDROGEN RECEPTOR-RELATED PROLIFERATION IN PROSTATIC-CARCINOMA DERIVED CELL-CULTURES

  • Authors:
    • T ZWERGEL
    • U BURK
    • S HERTER
    • T LINDENMEIR
    • B WULLICH
    • G UNTEREGGER
  • View Affiliations

  • Published online on: December 1, 1995     https://doi.org/10.3892/ijo.7.6.1339
  • Pages: 1339-1347
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Abstract

Our study reviews the central role of androgens for the development of androgen-insensitive growth in prostatic carcinoma using an individual dynamic model which emulates aspects of proliferation control. Our aim is the identification of individually proliferating cells from prostate carcinoma. Short-term cultured cells (n=205) from radical prostatectomy specimens have been used as the major method to skew the correspondence between the androgen-receptor (AR), proliferation-markers (Ki-67, PCNA) and morphological landmarks (nucleoli, AgNOR). These techniques allowed the identification of distinct androgen-insensitive, proliferating cell-clusters and in the future will allow the analysis of genotypic changes in identified proliferating cell clones.

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December 1995
Volume 7 Issue 6

Print ISSN: 1019-6439
Online ISSN:1791-2423

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APA
ZWERGEL, T., BURK, U., HERTER, S., LINDENMEIR, T., WULLICH, B., & UNTEREGGER, G. (1995). PHENOTYPIC CHARACTERIZATION OF ANDROGEN RECEPTOR-RELATED PROLIFERATION IN PROSTATIC-CARCINOMA DERIVED CELL-CULTURES. International Journal of Oncology, 7, 1339-1347. https://doi.org/10.3892/ijo.7.6.1339
MLA
ZWERGEL, T., BURK, U., HERTER, S., LINDENMEIR, T., WULLICH, B., UNTEREGGER, G."PHENOTYPIC CHARACTERIZATION OF ANDROGEN RECEPTOR-RELATED PROLIFERATION IN PROSTATIC-CARCINOMA DERIVED CELL-CULTURES". International Journal of Oncology 7.6 (1995): 1339-1347.
Chicago
ZWERGEL, T., BURK, U., HERTER, S., LINDENMEIR, T., WULLICH, B., UNTEREGGER, G."PHENOTYPIC CHARACTERIZATION OF ANDROGEN RECEPTOR-RELATED PROLIFERATION IN PROSTATIC-CARCINOMA DERIVED CELL-CULTURES". International Journal of Oncology 7, no. 6 (1995): 1339-1347. https://doi.org/10.3892/ijo.7.6.1339