INCREASED EXPRESSION OF BCL-2 IN DRUG-RESISTANT SQUAMOUS-CELL LUNG CARCINOMAS

  • Authors:
    • M VOLM
    • J MATTERN
  • View Affiliations

  • Published online on: December 1, 1995     https://doi.org/10.3892/ijo.7.6.1333
  • Pages: 1333-1338
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Abstract

The aim of this investigation was to prove whether or not an association exists between Bcl-2 expression and in vitro resistance to doxorubicin in biopsies of 85 human squamous cell lung carcinomas. Additionally, the relationship of Bcl-2 expression with resistance related proteins (P-glycoprotein, glutathione S-transferase-pi, catalase) was analyzed. Of the 85 carcinomas, 17 (20%) revealed Bcl-2 expression by immunohistochemistry. Seventeen of the tumors were classified as sensitive and 68 as resistant by an in vitro predictive test. All 17 Bcl-2-positive carcinomas were resistant to doxorubicin (p=0.018; chi(2)-test). A correlation was found between expression of Bcl-2 and expression of the resistance-related proteins P-glycoprotein and glutathione S-transferase-pi. The median survival time for patients with Bcl-2-negative carcinomas was two years and for Bcl-2-positive tumors over six years (log-rank test; p=0.08). Multivariate analysis (Cox regression model) revealed a borderline significant influence of Bcl-2 (p=0.07), whereas all other clinical factors (age, stage, metastasis) were of no significant influence on survival.

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December 1995
Volume 7 Issue 6

Print ISSN: 1019-6439
Online ISSN:1791-2423

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APA
VOLM, M., & VOLM, M. (1995). INCREASED EXPRESSION OF BCL-2 IN DRUG-RESISTANT SQUAMOUS-CELL LUNG CARCINOMAS. International Journal of Oncology, 7, 1333-1338. https://doi.org/10.3892/ijo.7.6.1333
MLA
VOLM, M., MATTERN, J."INCREASED EXPRESSION OF BCL-2 IN DRUG-RESISTANT SQUAMOUS-CELL LUNG CARCINOMAS". International Journal of Oncology 7.6 (1995): 1333-1338.
Chicago
VOLM, M., MATTERN, J."INCREASED EXPRESSION OF BCL-2 IN DRUG-RESISTANT SQUAMOUS-CELL LUNG CARCINOMAS". International Journal of Oncology 7, no. 6 (1995): 1333-1338. https://doi.org/10.3892/ijo.7.6.1333