PREVALENCE OF P53 OVEREXPRESSION OR MUTATIONS, BUT NOT K-RAS MUTATIONS, IN RECURRENT PATIENTS AFFECTED BY COLORECTAL-CARCINOMA

  • Authors:
    • P INIESTA
    • T CALDES
    • FJ VEGA
    • JA LOPEZ
    • E DIAZRUBIO
    • J CERDAN
    • A TORRES
    • JL BALIBREA
    • M BENITO
  • View Affiliations

  • Published online on: December 1, 1995     https://doi.org/10.3892/ijo.7.6.1319
  • Pages: 1319-1325
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Abstract

In order to establish prognostic indicators of poor clinical evolution in colorectal cancer, we have studied p53 abnormalities and K-ras mutations in 65 patients affected by colorectal carcinoma who had undergone radical surgery. A single event of p53 protein overexpression or p53 mutation, but not K-ras mutation, was significantly prevalent in recurrent tumors. A double event of K-ras mutation and p53 protein overexpression was prevalent in patients showing Dukes' stage C, but showed a lack of prevalence in patients who recurred. The presence of p53 protein overexpression does not assure an underlying mutation in colorectal carcinoma.

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December 1995
Volume 7 Issue 6

Print ISSN: 1019-6439
Online ISSN:1791-2423

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APA
INIESTA, P., CALDES, T., VEGA, F., LOPEZ, J., DIAZRUBIO, E., CERDAN, J. ... BENITO, M. (1995). PREVALENCE OF P53 OVEREXPRESSION OR MUTATIONS, BUT NOT K-RAS MUTATIONS, IN RECURRENT PATIENTS AFFECTED BY COLORECTAL-CARCINOMA. International Journal of Oncology, 7, 1319-1325. https://doi.org/10.3892/ijo.7.6.1319
MLA
INIESTA, P., CALDES, T., VEGA, F., LOPEZ, J., DIAZRUBIO, E., CERDAN, J., TORRES, A., BALIBREA, J., BENITO, M."PREVALENCE OF P53 OVEREXPRESSION OR MUTATIONS, BUT NOT K-RAS MUTATIONS, IN RECURRENT PATIENTS AFFECTED BY COLORECTAL-CARCINOMA". International Journal of Oncology 7.6 (1995): 1319-1325.
Chicago
INIESTA, P., CALDES, T., VEGA, F., LOPEZ, J., DIAZRUBIO, E., CERDAN, J., TORRES, A., BALIBREA, J., BENITO, M."PREVALENCE OF P53 OVEREXPRESSION OR MUTATIONS, BUT NOT K-RAS MUTATIONS, IN RECURRENT PATIENTS AFFECTED BY COLORECTAL-CARCINOMA". International Journal of Oncology 7, no. 6 (1995): 1319-1325. https://doi.org/10.3892/ijo.7.6.1319