DEREGULATION OF TYROSINE KINASES IN A RAT MACROPHAGE TUMOR - ECTOPIC EXPRESSION OF LCK

  • Authors:
    • TS SRIDHAR
    • V REMA
    • G SWARUP
    • A KHAR
  • View Affiliations

  • Published online on: February 1, 1995     https://doi.org/10.3892/ijo.6.2.487
  • Pages: 487-492
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Abstract

AK-5, a spontaneous rat macrophage tumor has 2-3 fold higher membrane-associated tyrosine kinase (TK) activity than normal peritoneal macrophages. lck, the lymphoid-specific TK, is expressed ectopically in AK-5. p56(lck), the protein product of lck, was detected in AK-5 by immunoprecipitation. The surface proteins CD4 and CD8 to which p56(lck) is complexed in lymphocytes are not present an the surface of AK-5. The transcripts of hck, a gene expressed predominantly in myeloid cells are markedly reduced in AK-5. The genomic organization of lck is unaltered. Although the total phosphotyrosine content of proteins is not altered significantly, there is a qualitative change in the profile of phosphotyrosine containing proteins. These results provide evidence for the ectopic expression of lck in a hematopoietic tumor and bolster the existing data implicating the participation of src family TKs in spontaneous neoplasms.

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February 1995
Volume 6 Issue 2

Print ISSN: 1019-6439
Online ISSN:1791-2423

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APA
SRIDHAR, T., REMA, V., SWARUP, G., & KHAR, A. (1995). DEREGULATION OF TYROSINE KINASES IN A RAT MACROPHAGE TUMOR - ECTOPIC EXPRESSION OF LCK. International Journal of Oncology, 6, 487-492. https://doi.org/10.3892/ijo.6.2.487
MLA
SRIDHAR, T., REMA, V., SWARUP, G., KHAR, A."DEREGULATION OF TYROSINE KINASES IN A RAT MACROPHAGE TUMOR - ECTOPIC EXPRESSION OF LCK". International Journal of Oncology 6.2 (1995): 487-492.
Chicago
SRIDHAR, T., REMA, V., SWARUP, G., KHAR, A."DEREGULATION OF TYROSINE KINASES IN A RAT MACROPHAGE TUMOR - ECTOPIC EXPRESSION OF LCK". International Journal of Oncology 6, no. 2 (1995): 487-492. https://doi.org/10.3892/ijo.6.2.487