A PHASE-II STUDY TESTING WEEKLY PLATINUM DERIVATIVE COMBINATION CHEMOTHERAPY AS 2ND-LINE TREATMENT IN PATIENTS WITH ADVANCED SMALL-CELL LUNG-CANCER

  • Authors:
    • JP SCULIER
    • J THIRIAUX
    • G BUREAU
    • JJ LAFITTE
    • P RECLOUX
    • D BROHEE
    • MC BERCHIER
    • R SERGYSELS
    • P MOMMEN
    • M PAESMANS
    • J KLASTERSKY
    • J LECOMTE
    • C VANSCHAARDENBURG
    • V RICHARD
    • D DIANA
    • F FORTIN
    • A TAGNON
    • U KUSTNER
  • View Affiliations

  • Published online on: February 1, 1995     https://doi.org/10.3892/ijo.6.2.425
  • Pages: 425-429
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Abstract

A phase II trial was conducted to determine the effectiveness of weekly administration of cisplatin (25 mg/m(2) on day 1) and carboplatin (100 mg/m(2) on day 1) as salvage chemotherapy for patients with small cell lung cancer after first-line chemotherapy without platinum derivatives. Of 40 eligible patients, 38 were evaluable for response. Interval between last course of first-line chemotherapy and first course of salvage therapy was less than 3 months in 34 and greater in 4. Five partial responses (13%; confidence interval at 95%:0.01-0.25) were documented (including 4 in patients with a treatment-free interval <3 months) as well as 8 no change, 21 progressions and 4 early deaths due to malignant disease. Toxicity consisted mainly of moderate thrombopenia and leucopenia. Grade I nephrotoxicity was observed in 6 patients. In conclusion, weekly administration of moderate doses of cisplatin and carboplatin as salvage chemotherapy for small cell lung cancer appeared feasible and was associated with a moderate but definitive anticancer activity.

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February 1995
Volume 6 Issue 2

Print ISSN: 1019-6439
Online ISSN:1791-2423

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APA
SCULIER, J., THIRIAUX, J., BUREAU, G., LAFITTE, J., RECLOUX, P., BROHEE, D. ... KUSTNER, U. (1995). A PHASE-II STUDY TESTING WEEKLY PLATINUM DERIVATIVE COMBINATION CHEMOTHERAPY AS 2ND-LINE TREATMENT IN PATIENTS WITH ADVANCED SMALL-CELL LUNG-CANCER. International Journal of Oncology, 6, 425-429. https://doi.org/10.3892/ijo.6.2.425
MLA
SCULIER, J., THIRIAUX, J., BUREAU, G., LAFITTE, J., RECLOUX, P., BROHEE, D., BERCHIER, M., SERGYSELS, R., MOMMEN, P., PAESMANS, M., KLASTERSKY, J., LECOMTE, J., VANSCHAARDENBURG, C., RICHARD, V., DIANA, D., FORTIN, F., TAGNON, A., KUSTNER, U."A PHASE-II STUDY TESTING WEEKLY PLATINUM DERIVATIVE COMBINATION CHEMOTHERAPY AS 2ND-LINE TREATMENT IN PATIENTS WITH ADVANCED SMALL-CELL LUNG-CANCER". International Journal of Oncology 6.2 (1995): 425-429.
Chicago
SCULIER, J., THIRIAUX, J., BUREAU, G., LAFITTE, J., RECLOUX, P., BROHEE, D., BERCHIER, M., SERGYSELS, R., MOMMEN, P., PAESMANS, M., KLASTERSKY, J., LECOMTE, J., VANSCHAARDENBURG, C., RICHARD, V., DIANA, D., FORTIN, F., TAGNON, A., KUSTNER, U."A PHASE-II STUDY TESTING WEEKLY PLATINUM DERIVATIVE COMBINATION CHEMOTHERAPY AS 2ND-LINE TREATMENT IN PATIENTS WITH ADVANCED SMALL-CELL LUNG-CANCER". International Journal of Oncology 6, no. 2 (1995): 425-429. https://doi.org/10.3892/ijo.6.2.425