EXPRESSION OF DESMOGLEIN-I CELL-ADHESION MOLECULE IN PRIMARY TUMORS AND METASTATIC LYMPH-NODES OF ESOPHAGEAL CANCER

  • Authors:
    • S NATSUGOE
    • M SAGARA
    • M SHIMADA
    • T KUMANOHOSO
    • K TOKUDA
    • D WAKAMATSU
    • Y TEZUKA
    • C KUSANO
    • H YOSHINAKA
    • M BABA
    • T FUKUMOTO
    • T AIKOU
  • View Affiliations

  • Published online on: February 1, 1995     https://doi.org/10.3892/ijo.6.2.345
  • Pages: 345-348
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Abstract

The expression of desmoglein I (DGI) in both primary turners and metastatic lymph node of esophageal carcinoma was studied immunohistochemically in 102 patients using an anti-DGI monoclonal antibody. Normal squamous epithelial cells strongly expressed DGI at their cell-cell boundaries. DGI expression in the tumors was divided into DGI (++), DGI (+), DGI (-) according to the staining intensity. DGI (+) or DG (-) tumors had lymph node metastases more frequently than DGI (++) tumors (p<0.01). DGI expression was the same or of less intensity, than in the primary tumor in 128 (85%) out of 151 metastatic lymph nodes. These results indicate that reduction or loss of DGI expression may promote lymph node metastases.

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February 1995
Volume 6 Issue 2

Print ISSN: 1019-6439
Online ISSN:1791-2423

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APA
NATSUGOE, S., SAGARA, M., SHIMADA, M., KUMANOHOSO, T., TOKUDA, K., WAKAMATSU, D. ... AIKOU, T. (1995). EXPRESSION OF DESMOGLEIN-I CELL-ADHESION MOLECULE IN PRIMARY TUMORS AND METASTATIC LYMPH-NODES OF ESOPHAGEAL CANCER. International Journal of Oncology, 6, 345-348. https://doi.org/10.3892/ijo.6.2.345
MLA
NATSUGOE, S., SAGARA, M., SHIMADA, M., KUMANOHOSO, T., TOKUDA, K., WAKAMATSU, D., TEZUKA, Y., KUSANO, C., YOSHINAKA, H., BABA, M., FUKUMOTO, T., AIKOU, T."EXPRESSION OF DESMOGLEIN-I CELL-ADHESION MOLECULE IN PRIMARY TUMORS AND METASTATIC LYMPH-NODES OF ESOPHAGEAL CANCER". International Journal of Oncology 6.2 (1995): 345-348.
Chicago
NATSUGOE, S., SAGARA, M., SHIMADA, M., KUMANOHOSO, T., TOKUDA, K., WAKAMATSU, D., TEZUKA, Y., KUSANO, C., YOSHINAKA, H., BABA, M., FUKUMOTO, T., AIKOU, T."EXPRESSION OF DESMOGLEIN-I CELL-ADHESION MOLECULE IN PRIMARY TUMORS AND METASTATIC LYMPH-NODES OF ESOPHAGEAL CANCER". International Journal of Oncology 6, no. 2 (1995): 345-348. https://doi.org/10.3892/ijo.6.2.345