PRECLINICAL STUDIES OF GOSSYPOL IN PROSTATE CARCINOMA
- HR NAIK
- D PETRYLAK
- A YAGODA
- JE LEHR
- A AKHTAR
- KJ PIENTA
Affiliations: WAYNE STATE UNIV,SCH MED,DIV HEMATOL & ONCOL,DETROIT,MI 48201. COLUMBIA PRESBYTERIAN MED CTR,DIV MED ONCOL,NEW YORK,NY 10032. UNIV MICHIGAN,SCH MED,DIV HEMATOL & ONCOL,ANN ARBOR,MI 48109.
- Published online on: January 1, 1995 https://doi.org/10.3892/ijo.6.1.209
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Hormone refractory prostate cancer remains an incurable disease and the discovery of newer agents with higher cytotoxic activity is required. Gossypol is a phenolic compound isolated from cottonseed oil which has been shown to have anti-spermatogenic effects. In in vitro studies, gossypol appears to inhibit the growth of rat prostate cancer cell line MAT-LyLu and human prostate adenocarcinoma cell lines PC-3, LNCaP and DU-145. In vive, gossypol appeared to inhibit tumor growth of subcutaneously implanted MAT-LyLu cells in Copenhagen rats. Gossypol may be an active agent for the treatment of hormone refractory metastatic prostate cancer.