HIGH-INCIDENCE OF ALLELIC LOSS AT THE RB GENE LOCUS IN ADVANCED HUMAN OVARIAN-CANCER
- H TAKANO
- A OKAMOTO
- Y TERASHIMA
- J YOKOTA
Affiliations: NATL CANC CTR,RES INST,DIV BIOL,CHUO KU,TOKYO 104,JAPAN. JIKEI UNIV,SCH MED,DEPT OBSTET & GYNECOL,MINATO KU,TOKYO 105,JAPAN.
- Published online on: January 1, 1995 https://doi.org/10.3892/ijo.6.1.129
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We examined 26 ovarian cancers for allelic losses at the loci of five tumor suppressor genes, p53, DCC, RB, APC and WT1. The loss of the p53 gene was most common among these five loci (13/20, 65%). The incidence of allelic loss at the RB locus was significantly higher in advanced stage (III-IV) (6/12, 50%) than in early stage (I-II) tumors (1/14, 7%). There were no cases in which the RB gene was lost but the p53 gene was retained. These results indicate that allelic loss of the RB gene locus occurs later than that of the p53 gene and plays a role in the progression of ovarian cancer.