GENETIC INSTABILITY IN MICROSATELLITE SEQUENCES IN PROSTATE-CANCER

  • Authors:
    • J KAGAN
    • LL PISTERS
    • P TRONCOSO
    • YS JOE
    • JM PARAT
    • RJ BABAIAN
    • AC VONESCHENBACH
  • View Affiliations

  • Published online on: October 1, 1994     https://doi.org/10.3892/ijo.5.4.921
  • Pages: 921-924
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Abstract

Mutations in microsatellite sequences, especially expansion in the number of di- and trinucleotide repeats, have been implicated as the cause of several heritable disorders, including fragile X syndrome and myotonic dystrophy. We examined the possibility that a similar mutation mechanism might be involved in human prostate cancer. Our findings indicate that mutations in microsatellite sequences are frequent in prostate cancer. Six of thirty patients (20%) had an allele gain in at least one microsatellite sequence; three patients (10%) had allele gains in multiple loci. The new alleles were present in the tumor DNA, but not in the normal DNA. Although we did not detect mutations in the androgen receptor microsatellite sequences, it is likely that this type of mutation affects other genes important in prostate cancer, thereby promoting tumor development and progression.

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October 1994
Volume 5 Issue 4

Print ISSN: 1019-6439
Online ISSN:1791-2423

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APA
KAGAN, J., PISTERS, L., TRONCOSO, P., JOE, Y., PARAT, J., BABAIAN, R., & VONESCHENBACH, A. (1994). GENETIC INSTABILITY IN MICROSATELLITE SEQUENCES IN PROSTATE-CANCER. International Journal of Oncology, 5, 921-924. https://doi.org/10.3892/ijo.5.4.921
MLA
KAGAN, J., PISTERS, L., TRONCOSO, P., JOE, Y., PARAT, J., BABAIAN, R., VONESCHENBACH, A."GENETIC INSTABILITY IN MICROSATELLITE SEQUENCES IN PROSTATE-CANCER". International Journal of Oncology 5.4 (1994): 921-924.
Chicago
KAGAN, J., PISTERS, L., TRONCOSO, P., JOE, Y., PARAT, J., BABAIAN, R., VONESCHENBACH, A."GENETIC INSTABILITY IN MICROSATELLITE SEQUENCES IN PROSTATE-CANCER". International Journal of Oncology 5, no. 4 (1994): 921-924. https://doi.org/10.3892/ijo.5.4.921