NUCLEAR-DNA CONTENT AND P53 IMMUNOSTAINING IN ORAL SQUAMOUS-CELL CARCINOMA - AN ANALYSIS OF A CONSECUTIVE 10-YEAR MATERIAL
- A HOGMO
- E MUNCKWIKLAND
- R KUYLENSTIERNA
- J LINDHOLM
- G AUER
Affiliations: KAROLINSKA HOSP,DEPT TUMOR PATHOL,S-10401 STOCKHOLM,SWEDEN.
- Published online on: October 1, 1994 https://doi.org/10.3892/ijo.5.4.915
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In a retrospective analysis of 91 consecutive oral carcinomas we reviewed all patient records and weighed clinicopathological parameters against the results of image DNA cytometry and p53 immunhistochemical staining of the initial diagnostic biopsies. Eighty-seven percent of the biopsies were either aneuploid or nondiploid and there was a significant correlation between poorly differentiated tumours and aneuploidy. Sixty-nine percent of the tumours were p53 positive. DNA aberration or p53 positivity had no significant impact on prediction of survival or susceptibility to radiotherapy. In a multivariate analysis, T category had the greatest predictive value concerning survival. There was no correlation between p53 positivity and smoking.