DNA-DAMAGE CAUSED BY ANTIBIOTIC DRUGS - QUINOLONES

  • Authors:
    • V MERSCHSUNDERMANN
    • KH HAUFF
    • P BRAUN
    • WQ LU
    • H HOF
  • View Affiliations

  • Published online on: October 1, 1994     https://doi.org/10.3892/ijo.5.4.855
  • Pages: 855-859
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Abstract

In the present investigation, the genotoxic potencies (SOSIP) of 10 antibiotic quinolones (topoisomerase LT inhibitors) were tested in the sfiA::lacZ fusion containing strain Escherichia coli PQ37 using a modified procedure of the SOS chromotest. A number of quinolones exhibited extremely high DNA damaging effects in the absence of an exogenous metabolizing system. The highest SOS inducing potencies (SOSIP) exhibited sparfloxacin with 2,400 Delta IF/nmole, ciprofloxacin (SOSIP = 184 Delta IF/nmole) and norfloxacin (SOSIP=120 Delta IF/nmole), whereas pipemic acid (SOSIP=4.6 Delta IF/nmole), cinoxacin (SOSIP=0.5 Delta IF/nmole) and nalidixic acid (SOSIP=0.5 Delta IF/nmole) showed only weak genotoxicity. The possibility of mutagenic effects caused by quinolones in eukaryotic cells is discussed.

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October 1994
Volume 5 Issue 4

Print ISSN: 1019-6439
Online ISSN:1791-2423

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APA
MERSCHSUNDERMANN, V., HAUFF, K., BRAUN, P., LU, W., & HOF, H. (1994). DNA-DAMAGE CAUSED BY ANTIBIOTIC DRUGS - QUINOLONES. International Journal of Oncology, 5, 855-859. https://doi.org/10.3892/ijo.5.4.855
MLA
MERSCHSUNDERMANN, V., HAUFF, K., BRAUN, P., LU, W., HOF, H."DNA-DAMAGE CAUSED BY ANTIBIOTIC DRUGS - QUINOLONES". International Journal of Oncology 5.4 (1994): 855-859.
Chicago
MERSCHSUNDERMANN, V., HAUFF, K., BRAUN, P., LU, W., HOF, H."DNA-DAMAGE CAUSED BY ANTIBIOTIC DRUGS - QUINOLONES". International Journal of Oncology 5, no. 4 (1994): 855-859. https://doi.org/10.3892/ijo.5.4.855