RESISTANCE FACTORS AND PROLIFERATIVE ACTIVITY IN CHILDHOOD ACUTE NONLYMPHOBLASTIC LEUKEMIA

  • Authors:
    • A SAUERBREY
    • F ZINTL
    • M VOLM
  • View Affiliations

  • Published online on: October 1, 1994     https://doi.org/10.3892/ijo.5.4.841
  • Pages: 841-846
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Thirty-four children with newly diagnosed acute nonlymphoblastic leukemia were analysed for the expression of P-glycoprotein (P-170), glutathione S-transferase-pi, (GST-pi) topoisomerase II (Topo II) and the proliferation antigen Ki-67 by the streptavidin-biotin-peroxidase method. Overexpression of P-170 was present in 26 cases (76%) and GST-pi overexpression was seen in 11 patients (32%). Down regulation of Topo II was found in 16 patients (47%) and Ki-67 positive cells (>5%) were detectable in 9 patients (26%). The remission rate was not influenced by P-170 or GST-pi expression, whereas patients with down regulation of Topo II or low Ki-67 expression had lower remission rates. The data were not significant. The probability of continuous first remission (CR) was lower in patients with P-170 expression (p=0.09). A significantly lower probability of CR was also seen in patients with low proliferative activity (p=0.03, log-rank test). The expression of the resistance proteins and the proliferative activity were found to be independent of the clinical parameters age, sex, FAB-type, and initial white blood cell count.

Related Articles

Journal Cover

October 1994
Volume 5 Issue 4

Print ISSN: 1019-6439
Online ISSN:1791-2423

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
APA
SAUERBREY, A., ZINTL, F., & VOLM, M. (1994). RESISTANCE FACTORS AND PROLIFERATIVE ACTIVITY IN CHILDHOOD ACUTE NONLYMPHOBLASTIC LEUKEMIA. International Journal of Oncology, 5, 841-846. https://doi.org/10.3892/ijo.5.4.841
MLA
SAUERBREY, A., ZINTL, F., VOLM, M."RESISTANCE FACTORS AND PROLIFERATIVE ACTIVITY IN CHILDHOOD ACUTE NONLYMPHOBLASTIC LEUKEMIA". International Journal of Oncology 5.4 (1994): 841-846.
Chicago
SAUERBREY, A., ZINTL, F., VOLM, M."RESISTANCE FACTORS AND PROLIFERATIVE ACTIVITY IN CHILDHOOD ACUTE NONLYMPHOBLASTIC LEUKEMIA". International Journal of Oncology 5, no. 4 (1994): 841-846. https://doi.org/10.3892/ijo.5.4.841