EFFECT OF RHG-CSF (FILGRASTIM) ON LEUKOCYTE KINETICS AND IMMUNE FUNCTION IN CYTOTOXIC CHEMOTHERAPY FOR GYNECOLOGIC MALIGNANCIES
- Authors:
- N TAKESHIMA
- S UMEZAWA
- Y SHIMIZU
- M FUKUDA
- M KIMURA
- K HASUMI
- Published online on: October 1, 1994 https://doi.org/10.3892/ijo.5.4.827
- Pages: 827-831
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Abstract
The effects of human recombinant granulocyte colony-stimulating factor (rhG-CSF) on leukocyte kinetics and immune function were assessed in patients with gynecologic malignancies receiving cytotoxic chemotherapy. Five day-rhG-CSF administration (50 mu g/m(2)/day) increased leukocyte counts in most of the chemotherapy courses. There was a significant difference in the leukocyte increase between the previously irradiated group and the nonirradiated group. An appreciable increase in LAK activity owing to an increased IL-2 production was noted after rhG-CSF administration. Despite a remarkable increase in the neutrophils observed, the CD57(+) cell count and NK activity in peripheral blood mononuclear cells were unexpectedly reduced.
