EFFECT OF RHG-CSF (FILGRASTIM) ON LEUKOCYTE KINETICS AND IMMUNE FUNCTION IN CYTOTOXIC CHEMOTHERAPY FOR GYNECOLOGIC MALIGNANCIES

  • Authors:
    • N TAKESHIMA
    • S UMEZAWA
    • Y SHIMIZU
    • M FUKUDA
    • M KIMURA
    • K HASUMI
  • View Affiliations

  • Published online on: October 1, 1994     https://doi.org/10.3892/ijo.5.4.827
  • Pages: 827-831
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Abstract

The effects of human recombinant granulocyte colony-stimulating factor (rhG-CSF) on leukocyte kinetics and immune function were assessed in patients with gynecologic malignancies receiving cytotoxic chemotherapy. Five day-rhG-CSF administration (50 mu g/m(2)/day) increased leukocyte counts in most of the chemotherapy courses. There was a significant difference in the leukocyte increase between the previously irradiated group and the nonirradiated group. An appreciable increase in LAK activity owing to an increased IL-2 production was noted after rhG-CSF administration. Despite a remarkable increase in the neutrophils observed, the CD57(+) cell count and NK activity in peripheral blood mononuclear cells were unexpectedly reduced.

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October 1994
Volume 5 Issue 4

Print ISSN: 1019-6439
Online ISSN:1791-2423

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APA
TAKESHIMA, N., UMEZAWA, S., SHIMIZU, Y., FUKUDA, M., KIMURA, M., & HASUMI, K. (1994). EFFECT OF RHG-CSF (FILGRASTIM) ON LEUKOCYTE KINETICS AND IMMUNE FUNCTION IN CYTOTOXIC CHEMOTHERAPY FOR GYNECOLOGIC MALIGNANCIES. International Journal of Oncology, 5, 827-831. https://doi.org/10.3892/ijo.5.4.827
MLA
TAKESHIMA, N., UMEZAWA, S., SHIMIZU, Y., FUKUDA, M., KIMURA, M., HASUMI, K."EFFECT OF RHG-CSF (FILGRASTIM) ON LEUKOCYTE KINETICS AND IMMUNE FUNCTION IN CYTOTOXIC CHEMOTHERAPY FOR GYNECOLOGIC MALIGNANCIES". International Journal of Oncology 5.4 (1994): 827-831.
Chicago
TAKESHIMA, N., UMEZAWA, S., SHIMIZU, Y., FUKUDA, M., KIMURA, M., HASUMI, K."EFFECT OF RHG-CSF (FILGRASTIM) ON LEUKOCYTE KINETICS AND IMMUNE FUNCTION IN CYTOTOXIC CHEMOTHERAPY FOR GYNECOLOGIC MALIGNANCIES". International Journal of Oncology 5, no. 4 (1994): 827-831. https://doi.org/10.3892/ijo.5.4.827