RELEASE OF EPIDERMAL GROWTH-FACTOR TRANSFORMING GROWTH-FACTOR-ALPHA BY OVARIAN-TUMORS IN-VITRO

  • Authors:
    • M RIDDERHEIM
    • A ANDERSSON
    • S CAJANDER
    • B TRIBUKAIT
    • U STENDAHL
    • T BACKSTROM
  • View Affiliations

  • Published online on: October 1, 1994     https://doi.org/10.3892/ijo.5.4.781
  • Pages: 781-786
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Abstract

EGF-like activity was measured in media from 3-hour incubations of ovarian tissue from 27 patients with normal postmenopausal ovaries, malignant or benign epithelial tumours. EGF-like activity in the medium was measured using a radioreceptor assay. Malignant tumour tissue released significantly more EGF/TGF-alpha than benign tissues and aneuploid carcinomas more than diploid carcinomas. In spite of varying amounts of tumour cells there was a strong correlation in EGF/TCF-alpha release from the different tissue samples of each patient suggesting paracrine rather than autocrine regulation. The level of EGF-like activity may be a feature of the patient rather than of the tumour cells.

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October 1994
Volume 5 Issue 4

Print ISSN: 1019-6439
Online ISSN:1791-2423

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APA
RIDDERHEIM, M., ANDERSSON, A., CAJANDER, S., TRIBUKAIT, B., STENDAHL, U., & BACKSTROM, T. (1994). RELEASE OF EPIDERMAL GROWTH-FACTOR TRANSFORMING GROWTH-FACTOR-ALPHA BY OVARIAN-TUMORS IN-VITRO. International Journal of Oncology, 5, 781-786. https://doi.org/10.3892/ijo.5.4.781
MLA
RIDDERHEIM, M., ANDERSSON, A., CAJANDER, S., TRIBUKAIT, B., STENDAHL, U., BACKSTROM, T."RELEASE OF EPIDERMAL GROWTH-FACTOR TRANSFORMING GROWTH-FACTOR-ALPHA BY OVARIAN-TUMORS IN-VITRO". International Journal of Oncology 5.4 (1994): 781-786.
Chicago
RIDDERHEIM, M., ANDERSSON, A., CAJANDER, S., TRIBUKAIT, B., STENDAHL, U., BACKSTROM, T."RELEASE OF EPIDERMAL GROWTH-FACTOR TRANSFORMING GROWTH-FACTOR-ALPHA BY OVARIAN-TUMORS IN-VITRO". International Journal of Oncology 5, no. 4 (1994): 781-786. https://doi.org/10.3892/ijo.5.4.781