TUMOR VASCULAR SHUTDOWN FOLLOWING PHOTODYNAMIC THERAPY BASED ON POLYHEMATOPORPHYRIN OR 5-AMINOLEVULINIC ACID

  • Authors:
    • DJH ROBERTS
    • F CAIRNDUFF
    • I DRIVER
    • B DIXON
    • SB BROWN
  • View Affiliations

  • Published online on: October 1, 1994     https://doi.org/10.3892/ijo.5.4.763
  • Pages: 763-768
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Abstract

The effects of photodynamic therapy (PDT) based on polyhaematoporphyrin (PHP) or 5-aminolaevulinic acid (ALA) on the tumour vascular perfusion (TVP) of a rat fibrosarcoma were examined using an (RbCl)-Rb-86 extraction technique. Both forms of therapy induced large and highly significant reductions in TVP, countering the previous suggestion that ALA-PDT has no vascular effects. Ultrasensitive digital imaging fluorescence microscopy indicated that ALA-induced PpIX was distributed relatively evenly throughout the tumour. Use of Hoechst 33342 as a vascular marker revealed that PpIX was also present in cells lining the tumour microvascular spaces, contrary to previous findings.

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October 1994
Volume 5 Issue 4

Print ISSN: 1019-6439
Online ISSN:1791-2423

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APA
ROBERTS, D., CAIRNDUFF, F., DRIVER, I., DIXON, B., & BROWN, S. (1994). TUMOR VASCULAR SHUTDOWN FOLLOWING PHOTODYNAMIC THERAPY BASED ON POLYHEMATOPORPHYRIN OR 5-AMINOLEVULINIC ACID. International Journal of Oncology, 5, 763-768. https://doi.org/10.3892/ijo.5.4.763
MLA
ROBERTS, D., CAIRNDUFF, F., DRIVER, I., DIXON, B., BROWN, S."TUMOR VASCULAR SHUTDOWN FOLLOWING PHOTODYNAMIC THERAPY BASED ON POLYHEMATOPORPHYRIN OR 5-AMINOLEVULINIC ACID". International Journal of Oncology 5.4 (1994): 763-768.
Chicago
ROBERTS, D., CAIRNDUFF, F., DRIVER, I., DIXON, B., BROWN, S."TUMOR VASCULAR SHUTDOWN FOLLOWING PHOTODYNAMIC THERAPY BASED ON POLYHEMATOPORPHYRIN OR 5-AMINOLEVULINIC ACID". International Journal of Oncology 5, no. 4 (1994): 763-768. https://doi.org/10.3892/ijo.5.4.763