TUMOR VASCULAR SHUTDOWN FOLLOWING PHOTODYNAMIC THERAPY BASED ON POLYHEMATOPORPHYRIN OR 5-AMINOLEVULINIC ACID
- DJH ROBERTS
- F CAIRNDUFF
- I DRIVER
- B DIXON
- SB BROWN
Affiliations: COOKRIDGE HOSP,DEPT CLIN ONCOL,LEEDS LS16 6QB,W YORKSHIRE,ENGLAND. COOKRIDGE HOSP,DEPT MED PHYS,LEEDS LS16 6QB,W YORKSHIRE,ENGLAND. UNIV LEEDS,DEPT BIOCHEM & MOLEC BIOL,LEEDS LS2 9JT,W YORKSHIRE,ENGLAND.
- Published online on: October 1, 1994 https://doi.org/10.3892/ijo.5.4.763
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The effects of photodynamic therapy (PDT) based on polyhaematoporphyrin (PHP) or 5-aminolaevulinic acid (ALA) on the tumour vascular perfusion (TVP) of a rat fibrosarcoma were examined using an (RbCl)-Rb-86 extraction technique. Both forms of therapy induced large and highly significant reductions in TVP, countering the previous suggestion that ALA-PDT has no vascular effects. Ultrasensitive digital imaging fluorescence microscopy indicated that ALA-induced PpIX was distributed relatively evenly throughout the tumour. Use of Hoechst 33342 as a vascular marker revealed that PpIX was also present in cells lining the tumour microvascular spaces, contrary to previous findings.