TRANSFORMING GROWTH-FACTOR-BETA (TGF-BETA) MESSENGER-RNA EXPRESSION AND GROWTH-CONTROL IN HUMAN LUNG SQUAMOUS CARCINOMA CELL-LINES

  • Authors:
    • JMS BARTLETT
    • GJ RABIASZ
    • SP LANGDON
    • EP MILLER
    • WR MILLER
  • View Affiliations

  • Published online on: February 1, 1994     https://doi.org/10.3892/ijo.4.2.475
  • Pages: 475-479
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Abstract

The pattern of TGF-beta mRNA expression and response to TGF-beta isoforms has been examined in three lung squamous carcinoma cell lines (NX002, CX140 and CX143). Expression for TGF-beta1 and TGF-beta2 but not TGF-beta3 was found in all 3 lines. TGF-beta1 and TGF-beta3 (but not TGF-beta2) inhibited the growth of the NX002 cell line in culture. The effect of TGF-beta1 on growth was accompanied with changes in the cell cycle. These data indicate that the potential for autocrine regulation by TGF-beta is present in lung squamous carcinoma cells.

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February 1994
Volume 4 Issue 2

Print ISSN: 1019-6439
Online ISSN:1791-2423

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APA
BARTLETT, J., RABIASZ, G., LANGDON, S., MILLER, E., & MILLER, W. (1994). TRANSFORMING GROWTH-FACTOR-BETA (TGF-BETA) MESSENGER-RNA EXPRESSION AND GROWTH-CONTROL IN HUMAN LUNG SQUAMOUS CARCINOMA CELL-LINES. International Journal of Oncology, 4, 475-479. https://doi.org/10.3892/ijo.4.2.475
MLA
BARTLETT, J., RABIASZ, G., LANGDON, S., MILLER, E., MILLER, W."TRANSFORMING GROWTH-FACTOR-BETA (TGF-BETA) MESSENGER-RNA EXPRESSION AND GROWTH-CONTROL IN HUMAN LUNG SQUAMOUS CARCINOMA CELL-LINES". International Journal of Oncology 4.2 (1994): 475-479.
Chicago
BARTLETT, J., RABIASZ, G., LANGDON, S., MILLER, E., MILLER, W."TRANSFORMING GROWTH-FACTOR-BETA (TGF-BETA) MESSENGER-RNA EXPRESSION AND GROWTH-CONTROL IN HUMAN LUNG SQUAMOUS CARCINOMA CELL-LINES". International Journal of Oncology 4, no. 2 (1994): 475-479. https://doi.org/10.3892/ijo.4.2.475