ELEVATED PRETREATMENT LEVELS OF SOLUBLE CD8 AND BETA-2-MICROGLOBULIN AS INDICATORS OF RELAPSE IN BREAST-CANCER PATIENTS

  • Authors:
    • B KLEIN
    • I LEVIN
    • H LURIE
    • A NYSKA
    • J SHAPIRA
    • M KRAVITS
    • T KLEIN
  • View Affiliations

  • Published online on: February 1, 1994     https://doi.org/10.3892/ijo.4.2.471
  • Pages: 471-474
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Abstract

We measured soluble CD8 ((S)CD8) and microglobulin (beta-2M) in 128 breast cancer patients and in 200 controls by the ELISA method. Patient groups were: Group A-new patients; Group B-patients on follow-up; Group C-patients with metastases. The mean (S)CD8 and beta-2M were significantly higher in patients than in controls ((S)CD8 p<0.01, beta-2M p<0.0001). Both for (S)CD8 and beta-2M, groups A and C had high levels which differed significantly from Group B ((S)CD8 p<0.04; beta-2M p<0.0001). A significant correlation between (S)CD8 and B-2M was observed (r=0.379: p=0.0001). Twenty patients relapsed. In 14/20 (70%) an initial high (S)CD8 and in 10/20 (50%), high beta-2M was observed. High initial CD8 and beta-2M were able to identify 80% of relapsed patients. High (S)CD8 and beta-2M levels are indicative of tumor bulk and are able to identify patients at

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February 1994
Volume 4 Issue 2

Print ISSN: 1019-6439
Online ISSN:1791-2423

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APA
KLEIN, B., LEVIN, I., LURIE, H., NYSKA, A., SHAPIRA, J., KRAVITS, M., & KLEIN, T. (1994). ELEVATED PRETREATMENT LEVELS OF SOLUBLE CD8 AND BETA-2-MICROGLOBULIN AS INDICATORS OF RELAPSE IN BREAST-CANCER PATIENTS. International Journal of Oncology, 4, 471-474. https://doi.org/10.3892/ijo.4.2.471
MLA
KLEIN, B., LEVIN, I., LURIE, H., NYSKA, A., SHAPIRA, J., KRAVITS, M., KLEIN, T."ELEVATED PRETREATMENT LEVELS OF SOLUBLE CD8 AND BETA-2-MICROGLOBULIN AS INDICATORS OF RELAPSE IN BREAST-CANCER PATIENTS". International Journal of Oncology 4.2 (1994): 471-474.
Chicago
KLEIN, B., LEVIN, I., LURIE, H., NYSKA, A., SHAPIRA, J., KRAVITS, M., KLEIN, T."ELEVATED PRETREATMENT LEVELS OF SOLUBLE CD8 AND BETA-2-MICROGLOBULIN AS INDICATORS OF RELAPSE IN BREAST-CANCER PATIENTS". International Journal of Oncology 4, no. 2 (1994): 471-474. https://doi.org/10.3892/ijo.4.2.471