IMMUNOHISTOCHEMICAL EXPRESSION OF THE C-FOS PROTEIN IN PRENEOPLASTIC AND NEOPLASTIC LESIONS DURING HEPATOCARCINOGENESIS IN RATS

  • Authors:
    • K ALEXANDRE
    • D FOKAN
    • P GALAND
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  • Published online on: February 1, 1994     https://doi.org/10.3892/ijo.4.2.429
  • Pages: 429-434
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Abstract

We performed an immunohistochemical study of the c-FOS protein, in the preneoplastic and neoplastic liver lesions in rats. The majority of the lesions at all stages contained an average of 50 to 60 percent of c-FOS immunopositive nuclei: This contrasted with the non-involved parenchyma, which exhibited a low incidence of positivity (less than 10 percent). No relation with proliferation or apoptosis was observed in the lesions, whereas the c-FOS protein was overexpressed within a few hours of partial hepatectomy. Moreover, our results indicate that increased c-FOS protein content is insufficient to elicit full malignancy.

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February 1994
Volume 4 Issue 2

Print ISSN: 1019-6439
Online ISSN:1791-2423

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APA
ALEXANDRE, K., FOKAN, D., & GALAND, P. (1994). IMMUNOHISTOCHEMICAL EXPRESSION OF THE C-FOS PROTEIN IN PRENEOPLASTIC AND NEOPLASTIC LESIONS DURING HEPATOCARCINOGENESIS IN RATS. International Journal of Oncology, 4, 429-434. https://doi.org/10.3892/ijo.4.2.429
MLA
ALEXANDRE, K., FOKAN, D., GALAND, P."IMMUNOHISTOCHEMICAL EXPRESSION OF THE C-FOS PROTEIN IN PRENEOPLASTIC AND NEOPLASTIC LESIONS DURING HEPATOCARCINOGENESIS IN RATS". International Journal of Oncology 4.2 (1994): 429-434.
Chicago
ALEXANDRE, K., FOKAN, D., GALAND, P."IMMUNOHISTOCHEMICAL EXPRESSION OF THE C-FOS PROTEIN IN PRENEOPLASTIC AND NEOPLASTIC LESIONS DURING HEPATOCARCINOGENESIS IN RATS". International Journal of Oncology 4, no. 2 (1994): 429-434. https://doi.org/10.3892/ijo.4.2.429