IMMUNOHISTOCHEMICAL EXPRESSION OF THE C-FOS PROTEIN IN PRENEOPLASTIC AND NEOPLASTIC LESIONS DURING HEPATOCARCINOGENESIS IN RATS
- K ALEXANDRE
- D FOKAN
- P GALAND
Affiliations: UNIV LIBRE BRUXELLES,IRIBHN,UNITE BIOL,B-1070 BRUSSELS,BELGIUM.
- Published online on: February 1, 1994 https://doi.org/10.3892/ijo.4.2.429
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We performed an immunohistochemical study of the c-FOS protein, in the preneoplastic and neoplastic liver lesions in rats. The majority of the lesions at all stages contained an average of 50 to 60 percent of c-FOS immunopositive nuclei: This contrasted with the non-involved parenchyma, which exhibited a low incidence of positivity (less than 10 percent). No relation with proliferation or apoptosis was observed in the lesions, whereas the c-FOS protein was overexpressed within a few hours of partial hepatectomy. Moreover, our results indicate that increased c-FOS protein content is insufficient to elicit full malignancy.