PROGNOSTIC-SIGNIFICANCE OF PROTEIN-KINASE-C IN NEWLY-DIAGNOSED CHILDHOOD ACUTE LYMPHOBLASTIC-LEUKEMIA

  • Authors:
    • M VOLM
    • A SAUERBREY
    • F ZINTL
  • View Affiliations

  • Published online on: February 1, 1994     https://doi.org/10.3892/ijo.4.2.363
  • Pages: 363-368
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

The expression of protein kinase C (PKC) was analysed in newly diagnosed cases of non-B acute lymphoblastic leukemia (NB-ALL) in children. Blast cells obtained from 104 children with untreated NB-ALL were analysed using the streptavidin-biotin-peroxidase method and the antibody MC5. Of the 104 patients with NB-ALL, 48 (=46%) showed positive staining for PKC. The relapse rate was significantly higher in NB-ALL with expression of PKC than in leukemia without expression of PKC (p=0.008). The relapse-free intervals in the PKC-negative leukemias were significantly longer than in cases of PKC-positive leukemias (p=0.004). The overall survival times were also longer in NB-ALL without expression of PKC than in ALL with PKC-expression (p=0.03). The results of univariate and multivariate analyses demonstrate that in addition to the clinical prognostic indicators PKC expression is a significant prognostic factor for relapse rate, relapse-free intervals, and overall survival times in NB-ALL of children.

Related Articles

Journal Cover

February 1994
Volume 4 Issue 2

Print ISSN: 1019-6439
Online ISSN:1791-2423

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
APA
VOLM, M., SAUERBREY, A., & ZINTL, F. (1994). PROGNOSTIC-SIGNIFICANCE OF PROTEIN-KINASE-C IN NEWLY-DIAGNOSED CHILDHOOD ACUTE LYMPHOBLASTIC-LEUKEMIA. International Journal of Oncology, 4, 363-368. https://doi.org/10.3892/ijo.4.2.363
MLA
VOLM, M., SAUERBREY, A., ZINTL, F."PROGNOSTIC-SIGNIFICANCE OF PROTEIN-KINASE-C IN NEWLY-DIAGNOSED CHILDHOOD ACUTE LYMPHOBLASTIC-LEUKEMIA". International Journal of Oncology 4.2 (1994): 363-368.
Chicago
VOLM, M., SAUERBREY, A., ZINTL, F."PROGNOSTIC-SIGNIFICANCE OF PROTEIN-KINASE-C IN NEWLY-DIAGNOSED CHILDHOOD ACUTE LYMPHOBLASTIC-LEUKEMIA". International Journal of Oncology 4, no. 2 (1994): 363-368. https://doi.org/10.3892/ijo.4.2.363