PHARMACOKINETICS OF CARBOPLATIN IN A PATIENT WITH BOTH TESTICULAR CANCER AND HEMODIALYSIS-REQUIRING KIDNEY FAILURE

  • Authors:
    • KS HALL
    • KP NORDAL
    • IB BREKKE
    • SD FOSSA
  • View Affiliations

  • Published online on: February 1, 1994     https://doi.org/10.3892/ijo.4.2.359
  • Pages: 359-362
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Abstract

We report on a patient with advanced seminoma successfully treated with 4 cycles of carboplatin (80-100 mg/m2 per cycle) and etoposide (240-300 mg/m2) while being on hemodialysis 3 times weekly. Hemodialysis was performed on day 2 and day 3 of each chemotherapy cycle. Plasma platinum levels were determined at regular intervals at days 1, 2 and 3 of each cycle. The drug doses for cycle 2-4 were reduced due to grade 4 hematological toxicity during the preceding cycle. In spite of these drug reductions the AUC between 0-51 h remained unchanged for all cycles. Platinum was found in the plasma collected on day 1 of cycle 2-4 prior to start of the scheduled carboplatin infusion. The demonstrated pharmacokinetics of carboplatin (and probably also of etoposide) should be considered during chemotherapy of a testicular cancer patient on hemodialysis.

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February 1994
Volume 4 Issue 2

Print ISSN: 1019-6439
Online ISSN:1791-2423

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APA
HALL, K., NORDAL, K., BREKKE, I., & FOSSA, S. (1994). PHARMACOKINETICS OF CARBOPLATIN IN A PATIENT WITH BOTH TESTICULAR CANCER AND HEMODIALYSIS-REQUIRING KIDNEY FAILURE. International Journal of Oncology, 4, 359-362. https://doi.org/10.3892/ijo.4.2.359
MLA
HALL, K., NORDAL, K., BREKKE, I., FOSSA, S."PHARMACOKINETICS OF CARBOPLATIN IN A PATIENT WITH BOTH TESTICULAR CANCER AND HEMODIALYSIS-REQUIRING KIDNEY FAILURE". International Journal of Oncology 4.2 (1994): 359-362.
Chicago
HALL, K., NORDAL, K., BREKKE, I., FOSSA, S."PHARMACOKINETICS OF CARBOPLATIN IN A PATIENT WITH BOTH TESTICULAR CANCER AND HEMODIALYSIS-REQUIRING KIDNEY FAILURE". International Journal of Oncology 4, no. 2 (1994): 359-362. https://doi.org/10.3892/ijo.4.2.359