NONRANDOM SECONDARY CHROMOSOME-ABERRATIONS IN LIPOSARCOMAS WITH T(12, 16)

  • Authors:
    • N MANDAHL
    • F MERTENS
    • P AMAN
    • A RYDHOLM
    • O BROSJO
    • H WILLEN
    • F MITELMAN
  • View Affiliations

  • Published online on: February 1, 1994     https://doi.org/10.3892/ijo.4.2.307
  • Pages: 307-310
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Abstract

Ten liposarcomas were analyzed cytogenetically after short-term culturing. Eight tumors had a t(12;16) (q13;p11) and two tumors had complex translocations involving chromosomes 7, 12, and 16 and 2, 9, 12, 16 and 20, respectively. Among the secondary aberrations seen in five tumors, +8 was found in two tumors and i(7)(q10) in four tumors. Trisomy 8 has previously been described as a nonrandom secondary aberration in myxoid liposarcoma, but i(7q) has only been reported in a single case before. All recurrent chromosome aberrations reported in liposarcomas with recombination between 12q13 and 16p11 (42 cases) were surveyed and compared with their frequencies in liposarcomas without this recombination (33 cases). Trisomy 5 and 8 were found in both tumor groups, whereas +19, t(3;15)(p23;q15), del(6)(q21), i(7q), and rearrangements of 1p11 and 2q35 were found exclusively in tumors with 12q13 and 16p11 aberrations.

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February 1994
Volume 4 Issue 2

Print ISSN: 1019-6439
Online ISSN:1791-2423

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APA
MANDAHL, N., MERTENS, F., AMAN, P., RYDHOLM, A., BROSJO, O., WILLEN, H., & MITELMAN, F. (1994). NONRANDOM SECONDARY CHROMOSOME-ABERRATIONS IN LIPOSARCOMAS WITH T(12, 16). International Journal of Oncology, 4, 307-310. https://doi.org/10.3892/ijo.4.2.307
MLA
MANDAHL, N., MERTENS, F., AMAN, P., RYDHOLM, A., BROSJO, O., WILLEN, H., MITELMAN, F."NONRANDOM SECONDARY CHROMOSOME-ABERRATIONS IN LIPOSARCOMAS WITH T(12, 16)". International Journal of Oncology 4.2 (1994): 307-310.
Chicago
MANDAHL, N., MERTENS, F., AMAN, P., RYDHOLM, A., BROSJO, O., WILLEN, H., MITELMAN, F."NONRANDOM SECONDARY CHROMOSOME-ABERRATIONS IN LIPOSARCOMAS WITH T(12, 16)". International Journal of Oncology 4, no. 2 (1994): 307-310. https://doi.org/10.3892/ijo.4.2.307