Prophylactic pelvic irradiation as part of primary therapy in uterine sarcomas

  • Authors:
    • Bengt Sorbe
    • Birgit Johansson
  • View Affiliations

  • Published online on: May 1, 2008     https://doi.org/10.3892/ijo.32.5.1111
  • Pages: 1111-1117
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

In a complete geographic series of 155 cases of primary uterine sarcomas, prophylactic pelvic irradiation was used as standard postoperative therapy in the majority of the cases. Vaginal brachytherapy was also added as a boost. The histology was leiomyosarcoma in 62 cases (40%), carcinosarcoma in 60 (39%), endometrial stromal sarcoma in 25 (16%), and other types in 8 cases (5%). The primary surgery was extended hysterectomy in 11 cases (7%), simple hysterectomy in 110 (71%), and supravaginal hysterectomy in 12 (8%). In 22 cases (14%) no major surgery was possible. In the complete series, 62 recurrences (40%) were recorded. Local (9%), regional (9%), and distant recurrences (28%) were the most frequent. The type of surgery was associated with the risk of tumor recurrence. Extended surgery reduced the risk of local and regional recurrences. The 5-year overall survival rate was 42% and the recurrence-free survival (RFS) was 37%. The number of mitoses was significantly (P=0.007) associated with survival. The locoregional RFS rate was 75% for patients treated with adjuvant irradiation and 83% for patients treated with primary surgery alone. Serious late tissue reactions from the bladder and intestine occurred in 7% of the irradiated cases. The locoregional tumor control rate was high in this series of patients, but no significant difference was found between patients treated with surgery alone and surgery plus postoperative pelvic irradiation. This was true for all histological subtypes of the uterine sarcomas. However, this was not a randomized study and selection bias cannot be ruled out.

Related Articles

Journal Cover

May 2008
Volume 32 Issue 5

Print ISSN: 1019-6439
Online ISSN:1791-2423

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
APA
Sorbe, B., & Sorbe, B. (2008). Prophylactic pelvic irradiation as part of primary therapy in uterine sarcomas. International Journal of Oncology, 32, 1111-1117. https://doi.org/10.3892/ijo.32.5.1111
MLA
Sorbe, B., Johansson, B."Prophylactic pelvic irradiation as part of primary therapy in uterine sarcomas". International Journal of Oncology 32.5 (2008): 1111-1117.
Chicago
Sorbe, B., Johansson, B."Prophylactic pelvic irradiation as part of primary therapy in uterine sarcomas". International Journal of Oncology 32, no. 5 (2008): 1111-1117. https://doi.org/10.3892/ijo.32.5.1111