MMTV-cre-mediated fur inactivation concomitant with PLAG1 proto-oncogene activation delays salivary gland tumorigenesis in mice

  • Authors:
    • Lieselot De Vos
    • Jeroen Declercq
    • Georgina Galicia Rosas
    • Boudewijn Van Damme
    • Anton Roebroek
    • Fons Vermorken
    • Jan Ceuppens
    • Wim van de Ven
    • John Creemers
  • View Affiliations

  • Published online on: May 1, 2008     https://doi.org/10.3892/ijo.32.5.1073
  • Pages: 1073-1083
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Proprotein convertases are serine endoproteases implicated in the proteolytic processing of a large variety of regulatory proteins. An important role of proprotein convertases in tumorigenic processes has been suggested by various studies. In this study, the role of the proprotein convertase furin in PLAG1 proto-oncogene-induced salivary gland tumorigenesis was investigated. PLAG1 overexpression in salivary glands has previously been shown to result in salivary gland tumors in 100% of mice within 5 weeks after birth. MMTV-cre-mediated inactivation of fur without over-expression of PLAG1 caused smaller but histologically normal salivary glands. Moreover, the lymph nodes close to the salivary glands were enlarged, and histology showed that they had activated follicles. When genetic ablation of 1 or 2 alleles of fur and overexpression of the PLAG1 transgene were simultaneously achieved, a significant delay in tumorigenesis was observed. Collectively, these results suggest an important role for furin in PLAG1-induced salivary gland tumorigenesis in mice.

Related Articles

Journal Cover

May 2008
Volume 32 Issue 5

Print ISSN: 1019-6439
Online ISSN:1791-2423

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
APA
De Vos, L., Declercq, J., Rosas, G.G., Van Damme, B., Roebroek, A., Vermorken, F. ... Creemers, J. (2008). MMTV-cre-mediated fur inactivation concomitant with PLAG1 proto-oncogene activation delays salivary gland tumorigenesis in mice. International Journal of Oncology, 32, 1073-1083. https://doi.org/10.3892/ijo.32.5.1073
MLA
De Vos, L., Declercq, J., Rosas, G. G., Van Damme, B., Roebroek, A., Vermorken, F., Ceuppens, J., van de Ven, W., Creemers, J."MMTV-cre-mediated fur inactivation concomitant with PLAG1 proto-oncogene activation delays salivary gland tumorigenesis in mice". International Journal of Oncology 32.5 (2008): 1073-1083.
Chicago
De Vos, L., Declercq, J., Rosas, G. G., Van Damme, B., Roebroek, A., Vermorken, F., Ceuppens, J., van de Ven, W., Creemers, J."MMTV-cre-mediated fur inactivation concomitant with PLAG1 proto-oncogene activation delays salivary gland tumorigenesis in mice". International Journal of Oncology 32, no. 5 (2008): 1073-1083. https://doi.org/10.3892/ijo.32.5.1073