Silencing of ZNF217 gene influences the biological behavior of a human ovarian cancer cell line

  • Authors:
    • Guiqin Sun
    • Jun Zhou
    • Ailan Yin
    • Yanqing Ding
    • Mei Zhong
  • View Affiliations

  • Published online on: May 1, 2008     https://doi.org/10.3892/ijo.32.5.1065
  • Pages: 1065-1071
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Abstract

Zinc-finger protein 217 (ZNF217), a candidate oncogene on 20q13.2, can lead cultured human ovarian and mammary epithelial cells to immortalization, which indicates selective expression of ZNF217 affecting 20q13 amplification during critical early stages of cancer progression. In this study, we tested the hypothesis that ZNF217 is a key factor in regulating ovarian cancer proliferation and progression. We examined the effect of the inhibition of ZNF217 expression on proliferation and invasion by establishing the ZNF217 knockdown ovarian cancer cell line using RNA interference (RNAi). Our results showed that silencing of ZNF217 resulted in the effective inhibition of ovarian cancer cell growth and invasive ability. The results suggested that ZNF217 might play a crucial role in the proliferation and invasion of ovarian cancer.

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May 2008
Volume 32 Issue 5

Print ISSN: 1019-6439
Online ISSN:1791-2423

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APA
Sun, G., Zhou, J., Yin, A., Ding, Y., & Zhong, M. (2008). Silencing of ZNF217 gene influences the biological behavior of a human ovarian cancer cell line. International Journal of Oncology, 32, 1065-1071. https://doi.org/10.3892/ijo.32.5.1065
MLA
Sun, G., Zhou, J., Yin, A., Ding, Y., Zhong, M."Silencing of ZNF217 gene influences the biological behavior of a human ovarian cancer cell line". International Journal of Oncology 32.5 (2008): 1065-1071.
Chicago
Sun, G., Zhou, J., Yin, A., Ding, Y., Zhong, M."Silencing of ZNF217 gene influences the biological behavior of a human ovarian cancer cell line". International Journal of Oncology 32, no. 5 (2008): 1065-1071. https://doi.org/10.3892/ijo.32.5.1065