Transferrin reverses the anti-invasive activity of human prostate cancer cells that overexpress sema3E

  • Authors:
    • Jeffery G. Herman
    • Gary G. Meadows
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  • Published online on: November 1, 2007     https://doi.org/10.3892/ijo.31.5.1267
  • Pages: 1267-1272
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Abstract

In vitro invasion and adhesion of stably semaphorin (sema) 3E-transfected PC-3 prostate cancer cells were determined in the presence and absence of transferrin. Invasion and adhesion decreased compared to untransfected cells; however, transferrin reversed the effects. Transferrin differentially regulated E-cadherin and β-catenin in these cells. Insulin growth factor 3 (IGFBP3) negated the invasive and adhesive effects of transferrin. Transferrin increased binding of insulin growth factor (IGF)-1 to the activated IGF-1 receptor, and IGF-1 mimicked the invasive and adhesive effects of transferrin. These data suggest that transferrin modulates sema3E-transfected cells through an IGFBP3/IGF-1-dependent pathway, in part, by regulation of adhesion proteins.

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November 2007
Volume 31 Issue 5

Print ISSN: 1019-6439
Online ISSN:1791-2423

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APA
Herman, J.G., & Herman, J.G. (2007). Transferrin reverses the anti-invasive activity of human prostate cancer cells that overexpress sema3E. International Journal of Oncology, 31, 1267-1272. https://doi.org/10.3892/ijo.31.5.1267
MLA
Herman, J. G., Meadows, G. G."Transferrin reverses the anti-invasive activity of human prostate cancer cells that overexpress sema3E". International Journal of Oncology 31.5 (2007): 1267-1272.
Chicago
Herman, J. G., Meadows, G. G."Transferrin reverses the anti-invasive activity of human prostate cancer cells that overexpress sema3E". International Journal of Oncology 31, no. 5 (2007): 1267-1272. https://doi.org/10.3892/ijo.31.5.1267