Overexpression of Septin1: Possible contribution to the development of oral cancer

  • Authors:
    • Yoshikuni Kato
    • Katsuhiro Uzawa
    • Nobuharu Yamamoto
    • Yukinao Kouzu
    • Hirofumi Koike
    • Masashi Shiiba
    • Hiroki Bukawa
    • Hidetaka Yokoe
    • Takahiko Shibahara
    • Hideki Tanzawa
  • View Affiliations

  • Published online on: November 1, 2007     https://doi.org/10.3892/ijo.31.5.1021
  • Pages: 1021-1028
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Our previous study using proteomic profiling demonstrated significant up-regulation of Septin1, a conserved family of GTPase proteins, in oral squamous-cell carcinoma (OSCC)-derived cell lines. In the current study, to determine the potential involvement of Septin1 in oral carcinogenesis, we evaluated the state of septin1 protein/mRNA expression in OSCC-derived cell lines, oral premalignant lesions (OPLs), and primary OSCCs. A significant (P<0.05) increase in Septin1 expression was evident in all OSCC-derived cell lines examined compared to human normal oral keratinocytes (HNOKs) and OPLs. In immunohistochemistry, while the vast majority of the OSCCs (89%) were positive for Septin1, no immunoreaction was observed in corresponding normal tissues and OPLs. In addition, real-time quantitative reverse transcriptase-polymerase chain reaction (QRT-PCR) data were consistent with the protein expression status. These results suggest that Septin1 expression could contribute to cancer progression, proliferation, or both, and that Septin1 may be a potential diagnostic marker of highly active cancer and a therapeutic target for OSCCs.

Related Articles

Journal Cover

November 2007
Volume 31 Issue 5

Print ISSN: 1019-6439
Online ISSN:1791-2423

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
APA
Kato, Y., Uzawa, K., Yamamoto, N., Kouzu, Y., Koike, H., Shiiba, M. ... Tanzawa, H. (2007). Overexpression of Septin1: Possible contribution to the development of oral cancer. International Journal of Oncology, 31, 1021-1028. https://doi.org/10.3892/ijo.31.5.1021
MLA
Kato, Y., Uzawa, K., Yamamoto, N., Kouzu, Y., Koike, H., Shiiba, M., Bukawa, H., Yokoe, H., Shibahara, T., Tanzawa, H."Overexpression of Septin1: Possible contribution to the development of oral cancer". International Journal of Oncology 31.5 (2007): 1021-1028.
Chicago
Kato, Y., Uzawa, K., Yamamoto, N., Kouzu, Y., Koike, H., Shiiba, M., Bukawa, H., Yokoe, H., Shibahara, T., Tanzawa, H."Overexpression of Septin1: Possible contribution to the development of oral cancer". International Journal of Oncology 31, no. 5 (2007): 1021-1028. https://doi.org/10.3892/ijo.31.5.1021