An automated nanoliter dispenser for staining individual biopsies in tissue microarrays

  • Authors:
    • Jared Slobodan
    • Dylan Gunn
    • Jason Thompson
    • Kurtis Guggenheimer
    • Keddie Brown
    • Mark Homenuke
    • Roy Belak
    • Diponkar Banerjee
    • David Broemeling
    • Andre Marziali
  • View Affiliations

  • Published online on: April 1, 2007     https://doi.org/10.3892/ijo.30.4.857
  • Pages: 857-863
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Abstract

In the field of molecular analysis of cancer, there exists a need for a clinical device that can automate protocols for immunohistochemical and in situ hybridization diagnostic staining on tissue microarrays. The tissue microarray antibody spotter (TMAS) has been developed to provide fundamental improvements over current histological staining techniques by enabling precision application of reagents to individual biopsies within a tissue microarray. This allows for multiplexed reactions on a single slide and promises to significantly reduce costs associated with immunohistochemistry and in situ hybridization based assays. Additionally, because TMAS allows for testing of different biomarkers on each element of a tissue array, a complete cancer profile can be obtained from a single TMA slide. Ultimately this may lead to cost-effective, faster and more accurate diagnosis of the patient.

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April 2007
Volume 30 Issue 4

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Copy and paste a formatted citation
APA
Slobodan, J., Gunn, D., Thompson, J., Guggenheimer, K., Brown, K., Homenuke, M. ... Marziali, A. (2007). An automated nanoliter dispenser for staining individual biopsies in tissue microarrays. International Journal of Oncology, 30, 857-863. https://doi.org/10.3892/ijo.30.4.857
MLA
Slobodan, J., Gunn, D., Thompson, J., Guggenheimer, K., Brown, K., Homenuke, M., Belak, R., Banerjee, D., Broemeling, D., Marziali, A."An automated nanoliter dispenser for staining individual biopsies in tissue microarrays". International Journal of Oncology 30.4 (2007): 857-863.
Chicago
Slobodan, J., Gunn, D., Thompson, J., Guggenheimer, K., Brown, K., Homenuke, M., Belak, R., Banerjee, D., Broemeling, D., Marziali, A."An automated nanoliter dispenser for staining individual biopsies in tissue microarrays". International Journal of Oncology 30, no. 4 (2007): 857-863. https://doi.org/10.3892/ijo.30.4.857