TNF expressed by tumor-associated macrophages, but not microglia, can eliminate glioma

  • Authors:
    • Jiro Nakagawa
    • Masanao Saio
    • Noriyuki Tamakawa
    • Tatsuhiko Suwa
    • Alan B. Frey
    • Kenichi Nonaka
    • Naoki Umemura
    • Hisashi Imai
    • Guan-Feng Ouyang
    • Naoyuki Ohe
    • Hirohito Yano
    • Sinichi Yoshimura
    • Toru Iwama
    • Tsuyoshi Takami
  • View Affiliations

  • Published online on: April 1, 2007     https://doi.org/10.3892/ijo.30.4.803
  • Pages: 803-811
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Abstract

It is well known that tumor necrosis factor (TNF) can have both contrary and pleiotropic effects in anti-tumor immune response. In the present study, we prepared two different tumor cell-based immunotherapy models: MCA38 adenocarcinoma and GL261 glioma intracranial interleukin-2 (IL-2)-based. Each tumor was transfected to express IL-2 with or without expression of the soluble form of tumor necrosis factor receptor type II (sTNFRII). Although mice in which TNF is blocked survive longer than IL-2 alone (35.2 versus 26 days), the reverse was observed for GL261 glioma. The differential effect on tumor growth implies enhanced TNF sensitivity of GL261 compared to MCA38. This notion is supported by the observation that TNF induces apoptosis in GL261 but not MCA38 tumors. We further examined tumor infiltrating CD11b+F4/80+ macrophages (or tumor-associated macrophages: TAM) for TNF production in vivo and found that TAM express cell surface TNF implying a role in eliminating glioma cells mediated by the cell surface form of TNF.

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April 2007
Volume 30 Issue 4

Print ISSN: 1019-6439
Online ISSN:1791-2423

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APA
Nakagawa, J., Saio, M., Tamakawa, N., Suwa, T., Frey, A.B., Nonaka, K. ... Takami, T. (2007). TNF expressed by tumor-associated macrophages, but not microglia, can eliminate glioma. International Journal of Oncology, 30, 803-811. https://doi.org/10.3892/ijo.30.4.803
MLA
Nakagawa, J., Saio, M., Tamakawa, N., Suwa, T., Frey, A. B., Nonaka, K., Umemura, N., Imai, H., Ouyang, G., Ohe, N., Yano, H., Yoshimura, S., Iwama, T., Takami, T."TNF expressed by tumor-associated macrophages, but not microglia, can eliminate glioma". International Journal of Oncology 30.4 (2007): 803-811.
Chicago
Nakagawa, J., Saio, M., Tamakawa, N., Suwa, T., Frey, A. B., Nonaka, K., Umemura, N., Imai, H., Ouyang, G., Ohe, N., Yano, H., Yoshimura, S., Iwama, T., Takami, T."TNF expressed by tumor-associated macrophages, but not microglia, can eliminate glioma". International Journal of Oncology 30, no. 4 (2007): 803-811. https://doi.org/10.3892/ijo.30.4.803