Immunization with MHC class I-negative but not -positive HPV16-associated tumour cells inhibits growth of MHC class I-negative tumours

  • Authors:
    • Milan Reinis
    • Jana Símová
    • Marie Indrová
    • Jana Bieblová
    • Hana Pribylová
    • Simona Moravcová
    • Tána Jandlová
    • Jan Bubeník
  • View Affiliations

  • Published online on: April 1, 2007     https://doi.org/10.3892/ijo.30.4.1011
  • Pages: 1011-1017
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Abstract

Loss or downregulation of MHC class I molecules on tumour cells is a common mechanism by which tumours can escape from T-cell mediated immune responses. In this study we have investigated the immunologic crossreactivity between murine tumour cell lines expressing human papilloma virus (HPV) 16-derived E6/E7 oncoproteins with distinct surface expression of MHC class I molecules. The aims of this study were to demonstrate whether immune responses capable of coping with MHC class I-positive tumours can also be effective against their MHC class I-deficient derivatives and whether it is possible to induce immunity against MHC class I-deficient tumours by cellular vaccines based on MHC class I-deficient tumour cell lines. Our data showed that immunization with MHC class I-deficient but not with MHC class I positive tumour cells inhibited the growth of MHC class I-deficient tumours. In vivo depletion studies revealed that the mechanisms underlying effective immune responses against MHC class I-negative tumours in animals immunized with MHC class I-deficient tumour cells involved natural killer cells. The presented findings are of particular clinical relevance in the sense of construction of vaccines directed against a broad spectrum of HPV-associated tumours.

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April 2007
Volume 30 Issue 4

Print ISSN: 1019-6439
Online ISSN:1791-2423

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APA
Reinis, M., Símová, J., Indrová, M., Bieblová, J., Pribylová, H., Moravcová, S. ... Bubeník, J. (2007). Immunization with MHC class I-negative but not -positive HPV16-associated tumour cells inhibits growth of MHC class I-negative tumours. International Journal of Oncology, 30, 1011-1017. https://doi.org/10.3892/ijo.30.4.1011
MLA
Reinis, M., Símová, J., Indrová, M., Bieblová, J., Pribylová, H., Moravcová, S., Jandlová, T., Bubeník, J."Immunization with MHC class I-negative but not -positive HPV16-associated tumour cells inhibits growth of MHC class I-negative tumours". International Journal of Oncology 30.4 (2007): 1011-1017.
Chicago
Reinis, M., Símová, J., Indrová, M., Bieblová, J., Pribylová, H., Moravcová, S., Jandlová, T., Bubeník, J."Immunization with MHC class I-negative but not -positive HPV16-associated tumour cells inhibits growth of MHC class I-negative tumours". International Journal of Oncology 30, no. 4 (2007): 1011-1017. https://doi.org/10.3892/ijo.30.4.1011