Effect of sulforaphane on cell growth, G0/G1 phase cell progression and apoptosis in human bladder cancer T24 cells

  • Authors:
    • Yujuan Shan
    • Changhao Sun
    • Xiujuan Zhao
    • Kun Wu
    • Aedin Cassidy
    • Yongping Bao
  • View Affiliations

  • Published online on: October 1, 2006     https://doi.org/10.3892/ijo.29.4.883
  • Pages: 883-888
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Abstract

Isothiocyanates (ITCs) from cruciferous vegetables have been shown to be effective in blocking initiation as well as progression of a range of chemically-induced tumors in animal models. In this study, sulforaphane, the most extensively studied ITC, was found to suppress the growth of T24 bladder cancer cells in vitro in a dose-dependent manner. Sulforaphane inhibited the proliferation of T24 cells with IC50 values 26.9 and 15.9 µM following 24 and 48 h treatments. Sulforaphane (5-20 µM) induced early apoptosis and blocked cell cycle progression at G0/G1 phase which was associated with upregulation of cyclin-dependent kinase inhibitor p27 expression. These results support a role for sulforaphane as an effective agent in the chemoprevention of bladder cancer.

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October 2006
Volume 29 Issue 4

Print ISSN: 1019-6439
Online ISSN:1791-2423

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APA
Shan, Y., Sun, C., Zhao, X., Wu, K., Cassidy, A., & Bao, Y. (2006). Effect of sulforaphane on cell growth, G0/G1 phase cell progression and apoptosis in human bladder cancer T24 cells. International Journal of Oncology, 29, 883-888. https://doi.org/10.3892/ijo.29.4.883
MLA
Shan, Y., Sun, C., Zhao, X., Wu, K., Cassidy, A., Bao, Y."Effect of sulforaphane on cell growth, G0/G1 phase cell progression and apoptosis in human bladder cancer T24 cells". International Journal of Oncology 29.4 (2006): 883-888.
Chicago
Shan, Y., Sun, C., Zhao, X., Wu, K., Cassidy, A., Bao, Y."Effect of sulforaphane on cell growth, G0/G1 phase cell progression and apoptosis in human bladder cancer T24 cells". International Journal of Oncology 29, no. 4 (2006): 883-888. https://doi.org/10.3892/ijo.29.4.883