Chromosomal end fusion resulting from telomere erosion increases susceptibility to radiation via multinucleation: Effect of p53

  • Authors:
    • Yeun-Jin Ju
    • Jeong Eun Park
    • Kyoung Mi Juhn
    • Jaemin Jeong
    • Miyong Yun
    • Myung-Jin Park
    • Gil-Hong Park
    • Kang-Yell Choi
    • Myung-Haeng Cho
    • Kwok-Kin Wong
    • Won-Bong Park
    • Kee-Ho Lee
  • View Affiliations

  • Published online on: October 1, 2006     https://doi.org/10.3892/ijo.29.4.753
  • Pages: 753-763
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Abstract

Loss of p53 tumor suppressor facilitates acquisition of telomerase activity. In fact, both p53 inactivation and telomerase activation are frequently found in human cancers. p53 inactivation, however, eliminates or attenuates the biological responses to telomerase inhibition and the eventual telomere erosion. We show that telomere erosion can increase the susceptibility to radiation, irrespective of p53 status. Both telomerase inhibition and critically shortened telomere with significant change of chromosomal end-to-end fusion were essential for the enhancement of radiosensitivity. The enhancement was correlated with greater formation of multinucleated cells. p53 inactivation did not eliminate the observed generation of chromosomal fusion and multinucleation, and the resulting increased susceptibility to radiation, as opposed to the previously proved role of p53 in mediating cellular responses to telomere dysfunction. The present findings suggest the importance of chromosomal end fusion in modulating radiosensitivity rather than p53 DNA damage signaling. Thus, the suggested anticancer radiotherapeutic strategy combined with telomerase inhibition could clinically be applicable to cancers, irrespective of p53 status.

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October 2006
Volume 29 Issue 4

Print ISSN: 1019-6439
Online ISSN:1791-2423

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APA
Ju, Y., Park, J.E., Juhn, K.M., Jeong, J., Yun, M., Park, M. ... Lee, K. (2006). Chromosomal end fusion resulting from telomere erosion increases susceptibility to radiation via multinucleation: Effect of p53. International Journal of Oncology, 29, 753-763. https://doi.org/10.3892/ijo.29.4.753
MLA
Ju, Y., Park, J. E., Juhn, K. M., Jeong, J., Yun, M., Park, M., Park, G., Choi, K., Cho, M., Wong, K., Park, W., Lee, K."Chromosomal end fusion resulting from telomere erosion increases susceptibility to radiation via multinucleation: Effect of p53". International Journal of Oncology 29.4 (2006): 753-763.
Chicago
Ju, Y., Park, J. E., Juhn, K. M., Jeong, J., Yun, M., Park, M., Park, G., Choi, K., Cho, M., Wong, K., Park, W., Lee, K."Chromosomal end fusion resulting from telomere erosion increases susceptibility to radiation via multinucleation: Effect of p53". International Journal of Oncology 29, no. 4 (2006): 753-763. https://doi.org/10.3892/ijo.29.4.753