EG-1 interacts with c-Src and activates its signaling pathway

  • Authors:
    • Ming Lu
    • Liping Zhang
    • Maryam R. Sartippour
    • Andrew J. Norris
    • Mai N. Brooks
  • View Affiliations

  • Published online on: October 1, 2006     https://doi.org/10.3892/ijo.29.4.1013
  • Pages: 1013-1018
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Abstract

EG-1 is significantly elevated in breast, colorectal, and prostate cancers. Overexpression of EG-1 stimulates cellular proliferation, and targeted inhibition blocks mouse xenograft tumor growth. To further clarify the function of EG-1, we investigated its role in c-Src activation. We observed that EG-1 overexpression results in activation of c-Src, but found no evidence that EG-1 is a direct Src substrate. EG-1 also binds to other members of the Src family. Furthermore, EG-1 shows interaction with multiple other SH3- and WW-containing molecules involved in various signaling pathways. These observations suggest that EG-1 may be involved in signaling pathways including c-Src activation.

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October 2006
Volume 29 Issue 4

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Copy and paste a formatted citation
APA
Lu, M., Zhang, L., Sartippour, M.R., Norris, A.J., & Brooks, M.N. (2006). EG-1 interacts with c-Src and activates its signaling pathway. International Journal of Oncology, 29, 1013-1018. https://doi.org/10.3892/ijo.29.4.1013
MLA
Lu, M., Zhang, L., Sartippour, M. R., Norris, A. J., Brooks, M. N."EG-1 interacts with c-Src and activates its signaling pathway". International Journal of Oncology 29.4 (2006): 1013-1018.
Chicago
Lu, M., Zhang, L., Sartippour, M. R., Norris, A. J., Brooks, M. N."EG-1 interacts with c-Src and activates its signaling pathway". International Journal of Oncology 29, no. 4 (2006): 1013-1018. https://doi.org/10.3892/ijo.29.4.1013