Ionizing radiation activates expression of FOXO3a, Fas ligand, and Bim, and induces cell apoptosis

  • Authors:
    • Jer-Yen Yang
    • Weiya Xia
    • Mickey C.-T. Hu
  • View Affiliations

  • Published online on: September 1, 2006     https://doi.org/10.3892/ijo.29.3.643
  • Pages: 643-648
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Abstract

Genotoxic stress such as ionizing radiation can induce DNA damage and promote cell-cycle arrest or apoptosis through either a p53-dependent or -independent pathway. Recently, members of the FOXO Forkhead transcription factor family have been implicated in playing a role in both DNA repair and apoptosis in mammalian cells that promoted us to examine the role of FOXO transcription factors in ionizing radiation-induced apoptosis. Here, we show that ionizing radiation can promote FOXO3a (FKHRL1) transcriptional activity and protein expression level, and induce nuclear translocation of FOXO3a in Saos2, a p53-null osteosarcoma cell line. Ionizing radiation stimulates expression of apoptosis-inducing proteins such as Fas ligand and the Bcl-2 interacting mediator of cell death (Bim) leading to cellular apoptosis. The observed upregulation of proapoptotic genes and apoptosis in cells without p53 in response to ionizing radiation suggests a novel p53-independent mechanism underlying ionizing radiation-induced apoptosis in cancer cells.

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September 2006
Volume 29 Issue 3

Print ISSN: 1019-6439
Online ISSN:1791-2423

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APA
Yang, J., Xia, W., & Hu, M.C. (2006). Ionizing radiation activates expression of FOXO3a, Fas ligand, and Bim, and induces cell apoptosis. International Journal of Oncology, 29, 643-648. https://doi.org/10.3892/ijo.29.3.643
MLA
Yang, J., Xia, W., Hu, M. C."Ionizing radiation activates expression of FOXO3a, Fas ligand, and Bim, and induces cell apoptosis". International Journal of Oncology 29.3 (2006): 643-648.
Chicago
Yang, J., Xia, W., Hu, M. C."Ionizing radiation activates expression of FOXO3a, Fas ligand, and Bim, and induces cell apoptosis". International Journal of Oncology 29, no. 3 (2006): 643-648. https://doi.org/10.3892/ijo.29.3.643