HAUSP as a therapeutic target for hematopoietic tumors (review)

  • Authors:
    • Kang Woo Cheon
    • Kwang-Hyun Baek
  • View Affiliations

  • Published online on: May 1, 2006     https://doi.org/10.3892/ijo.28.5.1209
  • Pages: 1209-1215
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

p53, one of the most important tumor suppressor proteins, plays an essential role in regulating the cell cycle and apoptosis by sensing the integrity of genome. Therefore, the level of p53 protein is critical for normal cellular homeostasis, and is known to be subtly regulated by ubiquitination and deubiquitination systems. Numerous genetic alterations of p53 have been reported in all types of tumors. In hematopoietic tumors, the mutations of p53 gene are rare compared with solid tumors, which showed more than 50% frequency for p53 mutations. According to this characteristic feature of hematological tumors, the therapeutic strategy for targeting the level of p53 may be valuable in anti-cancer treatment of hematological tumors. Herein, we deal with the post-translational regulation of p53 via its specific ubiquitinating enzymes (Mdm2, Mdmx, COP1, Pirh2, ARF-BP1/Mule, and CHIP) and a deubiquitinating enzyme, herpesvirus-associated ubiquitin-specific protease (HAUSP). In this article, we review the regulatory mechanism of p53 via ubiquitination and deubiquitination system and suggest the several possible therapeutic strategies of targeting HAUSP, a deubiquitinating enzyme for p53, for treating hematopoietic tumors.

Related Articles

Journal Cover

May 2006
Volume 28 Issue 5

Print ISSN: 1019-6439
Online ISSN:1791-2423

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
APA
Cheon, K.W., & Cheon, K.W. (2006). HAUSP as a therapeutic target for hematopoietic tumors (review). International Journal of Oncology, 28, 1209-1215. https://doi.org/10.3892/ijo.28.5.1209
MLA
Cheon, K. W., Baek, K."HAUSP as a therapeutic target for hematopoietic tumors (review)". International Journal of Oncology 28.5 (2006): 1209-1215.
Chicago
Cheon, K. W., Baek, K."HAUSP as a therapeutic target for hematopoietic tumors (review)". International Journal of Oncology 28, no. 5 (2006): 1209-1215. https://doi.org/10.3892/ijo.28.5.1209