Time-lag performance of radiofrequency ablation after percutaneous ethanol injection for the treatment of hepatocellular carcinoma

  • Authors:
    • Kazutaka Kurokohchi
    • Tsutomu Masaki
    • Seishiro Watanabe
    • Seiji Nakai
    • Akihiro Deguchi
    • Asahiro Morishita
    • Hirohito Yoneyama
    • Tomohiro Ohgi
    • Masahiro Ono
    • Akira Yoshitake
    • Takeshi Kako
    • Naoko Ohmachi
    • Takaaki Kiuchi
    • Tsuyoshi Maeta
    • Mitsuo Yoshida
    • Yoshihiro Mori
    • Fumikazu Kohi
    • Shigeki Kuriyama
  • View Affiliations

  • Published online on: April 1, 2006     https://doi.org/10.3892/ijo.28.4.971
  • Pages: 971-976
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Abstract

We have previously reported that the combination therapy of percutaneous ethanol injection and radiofrequency ablation (PEI-RFA) was more effective than RFA alone to induce wider coagulated necrosis for the treatment of hepatocellular carcinoma (HCC). In the present study, the effect of time-lag performance of RFA after PEI was evaluated under the same ablation condition as PEI-RFA by analyzing the volume of coagulated necrosis, the energy requirement for ablation and the amount of ethanol injected into HCC. The comparative study between time-lag PEI-RFA and no time-lag PEI-RFA showed that the total energy requirement and the energy requirement per unit volume for whole and marginal coagulated necrosis were significantly smaller in the time-lag group than in the no time-lag PEI-RFA group. In time-lag PEI-RFA, the volume of coagulated necrosis induced positively correlated with the amount of ethanol injected into HCC as previously observed in PEI-RFA treatment. These results suggest that time-lag PEI-RFA can induce comparable coagulated necrosis with a smaller energy requirement than no time-lag PEI-RFA, and that time-lag PEI-RFA is likely to be less invasive than no time-lag PEI-RFA for inducing comparable coagulated necrosis. Thus, time-lag performance of RFA after PEI may make RFA treatment more effective and less invasive for the treatment of patients with HCC.

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April 2006
Volume 28 Issue 4

Print ISSN: 1019-6439
Online ISSN:1791-2423

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APA
Kurokohchi, K., Masaki, T., Watanabe, S., Nakai, S., Deguchi, A., Morishita, A. ... Kuriyama, S. (2006). Time-lag performance of radiofrequency ablation after percutaneous ethanol injection for the treatment of hepatocellular carcinoma. International Journal of Oncology, 28, 971-976. https://doi.org/10.3892/ijo.28.4.971
MLA
Kurokohchi, K., Masaki, T., Watanabe, S., Nakai, S., Deguchi, A., Morishita, A., Yoneyama, H., Ohgi, T., Ono, M., Yoshitake, A., Kako, T., Ohmachi, N., Kiuchi, T., Maeta, T., Yoshida, M., Mori, Y., Kohi, F., Kuriyama, S."Time-lag performance of radiofrequency ablation after percutaneous ethanol injection for the treatment of hepatocellular carcinoma". International Journal of Oncology 28.4 (2006): 971-976.
Chicago
Kurokohchi, K., Masaki, T., Watanabe, S., Nakai, S., Deguchi, A., Morishita, A., Yoneyama, H., Ohgi, T., Ono, M., Yoshitake, A., Kako, T., Ohmachi, N., Kiuchi, T., Maeta, T., Yoshida, M., Mori, Y., Kohi, F., Kuriyama, S."Time-lag performance of radiofrequency ablation after percutaneous ethanol injection for the treatment of hepatocellular carcinoma". International Journal of Oncology 28, no. 4 (2006): 971-976. https://doi.org/10.3892/ijo.28.4.971