Survivin associates with cell proliferation in renal cancer cells: Regulation of survivin expression by insulin-like growth factor-1, interferon-γ and a novel NF-κB inhibitor

  • Authors:
    • Akinori Sato
    • Mototsugu Oya
    • Keiichi Ito
    • Ryuichi Mizuno
    • Yutaka Horiguchi
    • Kazuo Umezawa
    • Masamichi Hayakawa
    • Masaru Murai
  • View Affiliations

  • Published online on: April 1, 2006     https://doi.org/10.3892/ijo.28.4.841
  • Pages: 841-846
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Abstract

Although survivin has been widely recognized as an attractive target for cancer therapy, the exact mechanism regarding the regulation of survivin and its effect on cell proliferation have yet to be clearly defined in renal cell carcinoma (RCC). We investigated herein the association between survivin expression and cell proliferation in a RCC cell line, KU19-20. In KU19-20 cells, cell proliferation and survivin expression were significantly induced by IGF-1, whereas they were inhibited by a novel NF-κB inhibitor dehydroxymethyl-epoxyquinomicin (DHMEQ) and IFN-γ. The combination of DHMEQ and IFN-γ inhibited cell proliferation synergistically with a pronounced attenuation of survivin expression. Furthermore, treatment with survivin-specific siRNA reduced expression of survivin and significantly inhibited cell proliferation. Survivin expression was thus associated with cell proliferation in KU19-20 cells. The regulation of survivin by IFN-γ and/or an NF-κB inhibitor may therefore be a potential treatment modality for RCC.

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April 2006
Volume 28 Issue 4

Print ISSN: 1019-6439
Online ISSN:1791-2423

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APA
Sato, A., Oya, M., Ito, K., Mizuno, R., Horiguchi, Y., Umezawa, K. ... Murai, M. (2006). Survivin associates with cell proliferation in renal cancer cells: Regulation of survivin expression by insulin-like growth factor-1, interferon-γ and a novel NF-κB inhibitor. International Journal of Oncology, 28, 841-846. https://doi.org/10.3892/ijo.28.4.841
MLA
Sato, A., Oya, M., Ito, K., Mizuno, R., Horiguchi, Y., Umezawa, K., Hayakawa, M., Murai, M."Survivin associates with cell proliferation in renal cancer cells: Regulation of survivin expression by insulin-like growth factor-1, interferon-γ and a novel NF-κB inhibitor". International Journal of Oncology 28.4 (2006): 841-846.
Chicago
Sato, A., Oya, M., Ito, K., Mizuno, R., Horiguchi, Y., Umezawa, K., Hayakawa, M., Murai, M."Survivin associates with cell proliferation in renal cancer cells: Regulation of survivin expression by insulin-like growth factor-1, interferon-γ and a novel NF-κB inhibitor". International Journal of Oncology 28, no. 4 (2006): 841-846. https://doi.org/10.3892/ijo.28.4.841