Cytotoxicity of the polyamine oxidase inactivator MDL 72527 to cancer cells: Comparison with a saturated structural analogue

  • Authors:
    • Nikolaus Seiler
    • Jacques Renault
    • Francine Gossé
    • Stamatiki Roussi
    • Francis Raul
  • View Affiliations

  • Published online on: December 1, 2005     https://doi.org/10.3892/ijo.27.6.1669
  • Pages: 1669-1676
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

MDL 72527 (N1,N4-di-2,3-butadienyl-1,4-butanediamine) is a selective inactivator of polyamine oxidase with therapeutic potential. However, the development of lethal toxic effects due to prevention of spermine degradation is a considerable disadvantage of the compound. Since the cytotoxicity of MDL 72527 was postulated to be independent of its anti-polyamine oxidase activity, its cytotoxicity to cancer cells was compared with that of a close analogue that is devoid of structural features enabling mechanism-based inactivation of polyamine oxidase. N1,N4-di-n-butyl-1,4-butanediamine proved to be a cytotoxic agent of considerable potency, which induces mainly non-apoptotic cell death, whereas MDL 72527 causes under identical conditions both, apoptotic and non-apoptotic cell death. The sensitivity of cells to both compounds is presumably dependent of their glutathione content.

Related Articles

Journal Cover

December 2005
Volume 27 Issue 6

Print ISSN: 1019-6439
Online ISSN:1791-2423

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
APA
Seiler, N., Renault, J., Gossé, F., Roussi, S., & Raul, F. (2005). Cytotoxicity of the polyamine oxidase inactivator MDL 72527 to cancer cells: Comparison with a saturated structural analogue. International Journal of Oncology, 27, 1669-1676. https://doi.org/10.3892/ijo.27.6.1669
MLA
Seiler, N., Renault, J., Gossé, F., Roussi, S., Raul, F."Cytotoxicity of the polyamine oxidase inactivator MDL 72527 to cancer cells: Comparison with a saturated structural analogue". International Journal of Oncology 27.6 (2005): 1669-1676.
Chicago
Seiler, N., Renault, J., Gossé, F., Roussi, S., Raul, F."Cytotoxicity of the polyamine oxidase inactivator MDL 72527 to cancer cells: Comparison with a saturated structural analogue". International Journal of Oncology 27, no. 6 (2005): 1669-1676. https://doi.org/10.3892/ijo.27.6.1669