Expression of SIP1 in oral squamous cell carcinomas: implications for E-cadherin expression and tumor progression

  • Authors:
    • Genta Maeda
    • Tadashige Chiba
    • Masahiro Okazaki
    • Tazuko Satoh
    • Yuji Taya
    • Takaaki Aoba
    • Koroku Kato
    • Shuichi Kawashiri
    • Kazushi Imai
  • View Affiliations

  • Published online on: December 1, 2005     https://doi.org/10.3892/ijo.27.6.1535
  • Pages: 1535-1541
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Abstract

Loss of E-cadherin expression allows carcinoma cells to liberate from the primary site and enhances invasion and metastasis. The genetic aberration of E-cadherin is a rare event in sporadic carcinomas, and transcription repressors are considered to take a central role in E-cadherin loss. However, expression of E-cadherin repressors is largely dependent on tissue and cell type. To identify the repressor expressed in oral squamous carcinomas, we compared the expression levels of E-cadherin and repressors by real-time RT-PCR. Among the repressors including SNAIL, SLUG, SIP1, E12 and E47, SIP1 was inversely correlated to E-cadherin (P<0.05). Chromatin immunoprecipitation showed that SIP1 specifically bound to the E-cadherin promoter region. SIP1 expression was immuno-histochemically detected in 27.7% of 47 oral carcinomas, and SIP1-positive carcinomas did not express E-cadherin (P<0.01). Thirteen patients with SIP1 staining showed a lower disease-specific survival rate (P<0.05). Multivariate risk factor analysis demonstrated that SIP1 expression was an independent prognostic value for disease-specific overall survival (P<0.05). These results suggest that SIP1 contributes to the loss of E-cadherin expression and that detection of SIP1 expression is a predictive and prognostic tool in clinical management of oral carcinomas.

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December 2005
Volume 27 Issue 6

Print ISSN: 1019-6439
Online ISSN:1791-2423

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APA
Maeda, G., Chiba, T., Okazaki, M., Satoh, T., Taya, Y., Aoba, T. ... Imai, K. (2005). Expression of SIP1 in oral squamous cell carcinomas: implications for E-cadherin expression and tumor progression. International Journal of Oncology, 27, 1535-1541. https://doi.org/10.3892/ijo.27.6.1535
MLA
Maeda, G., Chiba, T., Okazaki, M., Satoh, T., Taya, Y., Aoba, T., Kato, K., Kawashiri, S., Imai, K."Expression of SIP1 in oral squamous cell carcinomas: implications for E-cadherin expression and tumor progression". International Journal of Oncology 27.6 (2005): 1535-1541.
Chicago
Maeda, G., Chiba, T., Okazaki, M., Satoh, T., Taya, Y., Aoba, T., Kato, K., Kawashiri, S., Imai, K."Expression of SIP1 in oral squamous cell carcinomas: implications for E-cadherin expression and tumor progression". International Journal of Oncology 27, no. 6 (2005): 1535-1541. https://doi.org/10.3892/ijo.27.6.1535