Expression of the licensing factors, Cdt1 and Geminin, in human colon cancer

  • Authors:
    • V. Bravou
    • H. Nishitani
    • S. Y. Song
    • S. Taraviras
    • J. Varakis
  • View Affiliations

  • Published online on: December 1, 2005     https://doi.org/10.3892/ijo.27.6.1511
  • Pages: 1511-1518
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Abstract

Licensing of chromatin for replication is an evolu-tionarily conserved step in the control of cell division and genomic integrity. Proteins that participate in licensing have been recently documented to denote the proliferative state of cells and they have been proposed as diagnostic and prognostic markers in human cancer. Cdt1 was recently discovered as an important licensing factor, that is inhibited by Geminin. In the present study we analyzed Cdt1 and Geminin expression in human colon cancer. We showed that Cdt1 protein is highly expressed in human neoplastic lesions of the colon while its cell-cycle phase-specific expression profile appears preserved during human carcinogenesis. Similarly, Geminin, Cdt1's inhibitor, is also overexpressed in colon carcinomas and its expression correlates with significant clinicopathological parameters of the disease. Moreover, both Cdt1 and Geminin expression are severely downregulated upon differentiation of Caco-2 cells, an in vitro model of intestinal epithelial differentiation.

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December 2005
Volume 27 Issue 6

Print ISSN: 1019-6439
Online ISSN:1791-2423

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APA
Bravou, V., Nishitani, H., Song, S.Y., Taraviras, S., & Varakis, J. (2005). Expression of the licensing factors, Cdt1 and Geminin, in human colon cancer. International Journal of Oncology, 27, 1511-1518. https://doi.org/10.3892/ijo.27.6.1511
MLA
Bravou, V., Nishitani, H., Song, S. Y., Taraviras, S., Varakis, J."Expression of the licensing factors, Cdt1 and Geminin, in human colon cancer". International Journal of Oncology 27.6 (2005): 1511-1518.
Chicago
Bravou, V., Nishitani, H., Song, S. Y., Taraviras, S., Varakis, J."Expression of the licensing factors, Cdt1 and Geminin, in human colon cancer". International Journal of Oncology 27, no. 6 (2005): 1511-1518. https://doi.org/10.3892/ijo.27.6.1511