Sex-based molecular profiling of hepatitis C virus-related hepatocellular carcinoma

  • Authors:
    • Norikazu Takemoto
    • Norio Iizuka
    • Hisafumi Yamada-Okabe
    • Kenji Hamada
    • Takao Tamesa
    • Toshimasa Okada
    • Kiichiro Hashimoto
    • Kazuhiko Sakamoto
    • Motonari Takashima
    • Takanobu Miyamoto
    • Shunji Uchimura
    • Yoshihiko Hamamoto
    • Masaaki Oka
  • View Affiliations

  • Published online on: March 1, 2005     https://doi.org/10.3892/ijo.26.3.673
  • Pages: 673-678
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

It has been suggested that sex affects not only the incidence of hepatocellular carcinoma (HCC) but also the outcome after treatment. However, no sex-specific therapeutic targets for HCC have been identified. Identification of sex-specific genes will allow for the development of more personalized therapies. To this end, we investigated the expression of approximately 6000 genes in 50 samples of hepatitis C virus (HCV)-related HCC by oligonucleotide microarray. Our supervised learning method and subsequent random permutation test identified 27 genes that were differentially expressed in samples from male (n=34) and female (n=16) patients. Our gene selection was validated by a false discovery rate of only 0.5%. For the 27 genes, expression levels of 12 were higher and expression levels of 15 were lower in HCC samples from men than in HCC samples from women. For the cell proliferation-related genes identified, expression levels of PRDX1 were relatively high in HCC samples from men, and expression levels of PRDX3 were relatively high in HCC samples from women. The DNA microarray data for PRDX1 and PRDX3 were reproduced by reverse transcription-PCR analysis. Our results suggest that these 27 genes may serve as molecular targets or markers for sex-specific treatment of HCV-related HCC. Further studies are needed to elucidate their possible roles in male and female patients with HCV-related HCC.

Related Articles

Journal Cover

March 2005
Volume 26 Issue 3

Print ISSN: 1019-6439
Online ISSN:1791-2423

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
APA
Takemoto, N., Iizuka, N., Yamada-Okabe, H., Hamada, K., Tamesa, T., Okada, T. ... Oka, M. (2005). Sex-based molecular profiling of hepatitis C virus-related hepatocellular carcinoma. International Journal of Oncology, 26, 673-678. https://doi.org/10.3892/ijo.26.3.673
MLA
Takemoto, N., Iizuka, N., Yamada-Okabe, H., Hamada, K., Tamesa, T., Okada, T., Hashimoto, K., Sakamoto, K., Takashima, M., Miyamoto, T., Uchimura, S., Hamamoto, Y., Oka, M."Sex-based molecular profiling of hepatitis C virus-related hepatocellular carcinoma". International Journal of Oncology 26.3 (2005): 673-678.
Chicago
Takemoto, N., Iizuka, N., Yamada-Okabe, H., Hamada, K., Tamesa, T., Okada, T., Hashimoto, K., Sakamoto, K., Takashima, M., Miyamoto, T., Uchimura, S., Hamamoto, Y., Oka, M."Sex-based molecular profiling of hepatitis C virus-related hepatocellular carcinoma". International Journal of Oncology 26, no. 3 (2005): 673-678. https://doi.org/10.3892/ijo.26.3.673