Identification of TCL1A as an immunohistochemical marker of adverse outcome in diffuse large B-cell lymphomas

  • Authors:
    • Olivier Ramuz
    • Reda Bouabdallah
    • Elisabeth Devilard
    • Nathalie Borie
    • Agnes Groulet-Martinec
    • Valérie-Jeanne Bardou
    • Pierre Brousset
    • François Bertucci
    • Françoise Birg
    • Daniel Birnbaum
    • Luc Xerri
  • View Affiliations

  • Published online on: January 1, 2005     https://doi.org/10.3892/ijo.26.1.151
  • Pages: 151-157
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Abstract

We used a combination of DNA-microarray and tissue-microarray (TMA) analyses to identify markers that could be routinely used to predict the outcome of diffuse large-B-cell lymphoma (DLCL) patients. Gene expression profiling was performed using DNA-microarrays on 52 tumour biopsy samples [31 DLCL and 21 follicular lymphomas (FL)] from 48 patients (28 DLCL and 20 FL). T-cell leukemia/lymphoma-1A (TCL1A) mRNA overexpression was correlated with relapse in DLCL patients. TMA analysis was applied on a distinct series of 36 formalin-fixed, paraffin-embedded DLCL samples and showed that TCL1A immunoexpression was correlated with either higher relapse (p=0.02) or lower 5-year overall survival (p=0.009) rates. Moreover, the prognostic value of TCL1A was independent from IPI in our series. Our data suggest that TCL1A immunodetection is an independent marker of adverse outcome that could be used in routine settings for the management of DLCL patients.

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January 2005
Volume 26 Issue 1

Print ISSN: 1019-6439
Online ISSN:1791-2423

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APA
Ramuz, O., Bouabdallah, R., Devilard, E., Borie, N., Groulet-Martinec, A., Bardou, V. ... Xerri, L. (2005). Identification of TCL1A as an immunohistochemical marker of adverse outcome in diffuse large B-cell lymphomas. International Journal of Oncology, 26, 151-157. https://doi.org/10.3892/ijo.26.1.151
MLA
Ramuz, O., Bouabdallah, R., Devilard, E., Borie, N., Groulet-Martinec, A., Bardou, V., Brousset, P., Bertucci, F., Birg, F., Birnbaum, D., Xerri, L."Identification of TCL1A as an immunohistochemical marker of adverse outcome in diffuse large B-cell lymphomas". International Journal of Oncology 26.1 (2005): 151-157.
Chicago
Ramuz, O., Bouabdallah, R., Devilard, E., Borie, N., Groulet-Martinec, A., Bardou, V., Brousset, P., Bertucci, F., Birg, F., Birnbaum, D., Xerri, L."Identification of TCL1A as an immunohistochemical marker of adverse outcome in diffuse large B-cell lymphomas". International Journal of Oncology 26, no. 1 (2005): 151-157. https://doi.org/10.3892/ijo.26.1.151