Galectin-3 and cancer (Review).

  • Authors:
    • Stéphane Califice
    • Vincent Castronovo
    • Frédéric Van Den Brûle
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  • Published online on: October 1, 2004     https://doi.org/10.3892/ijo.25.4.983
  • Pages: 983-1075
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Abstract

Galectin-3 is a pleiotropic carbohydrate-binding protein involved in a variety of normal and pathological biological processes. Its carbohydrate-binding properties constitute the basis for cell-cell and cell-matrix interactions and cancer progression. Modulation of galectin-3 expression in cancer cells has indeed been reported. These observations lead to the recognition of galectin-3 as a diagnostic/prognostic marker for specific cancer types, such as thyroid and prostate. This review discusses the expression and cellular localization of galectin-3 in cancer cells, as well as its numerous functions in cancer cell biology, including cell-cell adhesion, cell-matrix interactions, growth regulation, apoptosis, angiogenesis and mRNA splicing.

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October 2004
Volume 25 Issue 4

Print ISSN: 1019-6439
Online ISSN:1791-2423

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APA
Califice, S., Castronovo, V., & Van Den Brûle, F. (2004). Galectin-3 and cancer (Review).. International Journal of Oncology, 25, 983-1075. https://doi.org/10.3892/ijo.25.4.983
MLA
Califice, S., Castronovo, V., Van Den Brûle, F."Galectin-3 and cancer (Review).". International Journal of Oncology 25.4 (2004): 983-1075.
Chicago
Califice, S., Castronovo, V., Van Den Brûle, F."Galectin-3 and cancer (Review).". International Journal of Oncology 25, no. 4 (2004): 983-1075. https://doi.org/10.3892/ijo.25.4.983