Bone marrow microenvironment facilitating dendritic cell: CD4 T cell interactions and maintenance of CD4 memory

  • Authors:
    • Markus Feuerer
    • Philipp Beckhove
    • Yolanda Mahnke
    • Mirja Hommel
    • Bruno Kyewski
    • Alf Hamann
    • Viktor Umansky
    • Volker Schirrmacher
  • View Affiliations

  • Published online on: October 1, 2004     https://doi.org/10.3892/ijo.25.4.867
  • Pages: 867-876
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Abstract

This study shows that bone marrow (BM) stroma expresses constitutively multiple adhesion molecules (ICAM-1, VCAM-1, MadCAM-1, P-selectin) relevant for the homing and infiltration of BM by blood derived T lymphocytes, and also the co-stimulatory molecule CD80, relevant for T cell activation. T cells were capable of homing to BM but not to thymus. Homing to BM involved the integrins LFA-1α and α4 which interact with the above constitutively expressed cell adhesion molecules (CAMs). CD3 T cells were detected together with BM resident CD11c dendritic cells (DCs), often enriched in follicle-like structures in BM parenchyma. Cognate interactions between transferred antigen specific transgenic CD4 T cells and antigen laden BM-DCs led to formation of multicellular clusters in situ in BM, to generation of lymphoblasts and to clonal T cell expansion within such clusters. The great majority of BM-CD4 T cells had a memory phenotype suggesting that the BM microenvironment facilitates maintenance of CD4 memory. These results extend and corroborate our previous findings on BM-CD8 T cell mediated immune responses. Together these findings suggest that DC-T cell interactions in BM play an important role in immune responses to blood-borne antigen and in the establishment of systemic immunity and long-term memory.

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October 2004
Volume 25 Issue 4

Print ISSN: 1019-6439
Online ISSN:1791-2423

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APA
Feuerer, M., Beckhove, P., Mahnke, Y., Hommel, M., Kyewski, B., Hamann, A. ... Schirrmacher, V. (2004). Bone marrow microenvironment facilitating dendritic cell: CD4 T cell interactions and maintenance of CD4 memory. International Journal of Oncology, 25, 867-876. https://doi.org/10.3892/ijo.25.4.867
MLA
Feuerer, M., Beckhove, P., Mahnke, Y., Hommel, M., Kyewski, B., Hamann, A., Umansky, V., Schirrmacher, V."Bone marrow microenvironment facilitating dendritic cell: CD4 T cell interactions and maintenance of CD4 memory". International Journal of Oncology 25.4 (2004): 867-876.
Chicago
Feuerer, M., Beckhove, P., Mahnke, Y., Hommel, M., Kyewski, B., Hamann, A., Umansky, V., Schirrmacher, V."Bone marrow microenvironment facilitating dendritic cell: CD4 T cell interactions and maintenance of CD4 memory". International Journal of Oncology 25, no. 4 (2004): 867-876. https://doi.org/10.3892/ijo.25.4.867