Angiotensin II activates MAP kinase and NF-κB through angiotensin II type I receptor in human pancreatic cancer cells

  • Authors:
    • Koji Amaya
    • Tetsuo Ohta
    • Hirohisa Kitagawa
    • Masato Kayahara
    • Hiroyuki Takamura
    • Takashi Fujimura
    • Gen-Ichi Nishimura
    • Koichi Shimizu
    • Koichi Miwa
  • View Affiliations

  • Published online on: October 1, 2004     https://doi.org/10.3892/ijo.25.4.849
  • Pages: 849-856
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Abstract

Pancreatic ductal cancer has higher angiotensin II concentrations compared with normal pancreas or other solid tumors. This study examined angiotensin II type 1 (AT1) receptor expression and the role of angiotensin II in proliferation and survival of human pancreatic cancer cells. All three pancreatic cancer cell lines studied, from well to poorly-differentiated types, HPAF-II, AsPC-1, and Panc-1, showed strong expression of AT1 receptor. In contrast, HT-29 human colon cancer cells showed extremely weak expression. Angiotensin II stimulated the growth of pancreatic cancer cells through MAP kinase activation but had no significant effect on proliferation of HT-29 colon cancer cells. In addition, angiotensin II significantly prevented cisplatin (CDDP)-induced apoptosis through NF-κB activation and the subsequent production of anti-apoptotic molecules, including survivin and Bcl-XL, in pancreatic cancer cells. These findings suggest that angiotensin II plays a role in the growth and chemoresistance of AT1-positive pancreatic cancer cells through its action as a potent mitogen and anti-apoptotic molecule.

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October 2004
Volume 25 Issue 4

Print ISSN: 1019-6439
Online ISSN:1791-2423

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APA
Amaya, K., Ohta, T., Kitagawa, H., Kayahara, M., Takamura, H., Fujimura, T. ... Miwa, K. (2004). Angiotensin II activates MAP kinase and NF-κB through angiotensin II type I receptor in human pancreatic cancer cells. International Journal of Oncology, 25, 849-856. https://doi.org/10.3892/ijo.25.4.849
MLA
Amaya, K., Ohta, T., Kitagawa, H., Kayahara, M., Takamura, H., Fujimura, T., Nishimura, G., Shimizu, K., Miwa, K."Angiotensin II activates MAP kinase and NF-κB through angiotensin II type I receptor in human pancreatic cancer cells". International Journal of Oncology 25.4 (2004): 849-856.
Chicago
Amaya, K., Ohta, T., Kitagawa, H., Kayahara, M., Takamura, H., Fujimura, T., Nishimura, G., Shimizu, K., Miwa, K."Angiotensin II activates MAP kinase and NF-κB through angiotensin II type I receptor in human pancreatic cancer cells". International Journal of Oncology 25, no. 4 (2004): 849-856. https://doi.org/10.3892/ijo.25.4.849