A novel 4,4'-bispyridyl-5,5'-perfluoroalkyl-2,2'-bisoxazol with antitumoral activity via cell cycle arrest and induction of apoptosis.

  • Authors:
    • Mónica Báñez-Coronel
    • Agustín Rodríguez-González
    • Yolanda Martín-Cantalejo
    • Beatriz Sáez
    • Javier Soto
    • M Jesús Villa
    • Miguel F Braña
    • Juan Carlos Lacal
  • View Affiliations

  • Published online on: October 1, 2004     https://doi.org/10.3892/ijo.25.4.1097
  • Pages: 1097-1200
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Abstract

The compound 6a is a novel bisoxazol derivative with high cytotoxic properties in vitro against different human tumor-derived cell lines and with similar efficiency against epithelial, haematopoietic and mesenchymal tumor cells. Although the molecular mechanism is not yet fully defined, cell cycle analysis revealed that 6a induces efficiently G0/G1 phase arrest in colon adenocarcinoma HT-29 cells in a dose- and time-dependent manner. Induction of cell death is observed, a possible explanation for the antiproliferative profile of the molecule. The compound was well tolerated at doses that allowed to examine its antitumor activity against human xenografts of the HT-29 cell line implanted s.c. in nude mice. Treatment of mice with 4 mg/kg of the compound resulted in a 60% inhibition of tumor growth. These observations support the use of 6a for the generation of more potent derivatives that could be used as new anticancer agents.

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October 2004
Volume 25 Issue 4

Print ISSN: 1019-6439
Online ISSN:1791-2423

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APA
Báñez-Coronel, M., Rodríguez-González, A., Martín-Cantalejo, Y., Sáez, B., Soto, J., Villa, M. ... Lacal, J. (2004). A novel 4,4'-bispyridyl-5,5'-perfluoroalkyl-2,2'-bisoxazol with antitumoral activity via cell cycle arrest and induction of apoptosis.. International Journal of Oncology, 25, 1097-1200. https://doi.org/10.3892/ijo.25.4.1097
MLA
Báñez-Coronel, M., Rodríguez-González, A., Martín-Cantalejo, Y., Sáez, B., Soto, J., Villa, M., Braña, M., Lacal, J."A novel 4,4'-bispyridyl-5,5'-perfluoroalkyl-2,2'-bisoxazol with antitumoral activity via cell cycle arrest and induction of apoptosis.". International Journal of Oncology 25.4 (2004): 1097-1200.
Chicago
Báñez-Coronel, M., Rodríguez-González, A., Martín-Cantalejo, Y., Sáez, B., Soto, J., Villa, M., Braña, M., Lacal, J."A novel 4,4'-bispyridyl-5,5'-perfluoroalkyl-2,2'-bisoxazol with antitumoral activity via cell cycle arrest and induction of apoptosis.". International Journal of Oncology 25, no. 4 (2004): 1097-1200. https://doi.org/10.3892/ijo.25.4.1097