Loss of heterozygosity at chromosome 9q22-31 is a frequent and early event in ovarian tumors

  • Authors:
    • Jennifer Byrom
    • Vivek Mudaliar
    • Charles W. Redman
    • Peter Jones
    • Richard C. Strange
    • Paul R. Hoban
  • View Affiliations

  • Published online on: May 1, 2004     https://doi.org/10.3892/ijo.24.5.1271
  • Pages: 1271-1277
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Abstract

Loss of heterozygosity (LOH) studies in ovarian tumors, have highlighted the chromosomal regions at 9q22-31 and 9q32-34 as being potentially important in tumor development. We have investigated LOH at 9q22-31 in 85 patients with epithelial ovarian cancer, 15 with non-epithelial tumors and 16 with benign disease. Varying patterns of LOH were observed across the markers used between different tumors, the most common (71%) being interstitial discontinuous losses. LOH was frequent, and was detected at equally high levels in malignant (71%) and benign tumors (70%). LOH occurred in epithelial invasive tumors, borderline tumors, fibromas and dermoid tumors. In malignant epithelial tumors LOH at 9q22-31 was not significantly associated with patient clinical and pathological parameters; however, survival was 29 months at the 50th centile survival, in those women whose tumors displayed LOH compared with 60 months in women whose tumors retained heterozygosity. LOH at 9q22-31 was significantly associated with LOH at the p53 locus (p=0.02) and the ovarian suppressor locus at 3p21 (p=0.05). We conclude that the chromosome region at 9q22-31, flanked by the microsatellite markers D9S1796 and D9S53, is a frequent and early event in ovarian tumorigenesis. With the of extent of discontinuous LOH, high density deletion mapping of this region using LOH as a strategy to identify candidate genes may be problematic. However with the completion of the human genome sequencing project several candidate genes are identified.

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May 2004
Volume 24 Issue 5

Print ISSN: 1019-6439
Online ISSN:1791-2423

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APA
Byrom, J., Mudaliar, V., Redman, C.W., Jones, P., Strange, R.C., & Hoban, P.R. (2004). Loss of heterozygosity at chromosome 9q22-31 is a frequent and early event in ovarian tumors. International Journal of Oncology, 24, 1271-1277. https://doi.org/10.3892/ijo.24.5.1271
MLA
Byrom, J., Mudaliar, V., Redman, C. W., Jones, P., Strange, R. C., Hoban, P. R."Loss of heterozygosity at chromosome 9q22-31 is a frequent and early event in ovarian tumors". International Journal of Oncology 24.5 (2004): 1271-1277.
Chicago
Byrom, J., Mudaliar, V., Redman, C. W., Jones, P., Strange, R. C., Hoban, P. R."Loss of heterozygosity at chromosome 9q22-31 is a frequent and early event in ovarian tumors". International Journal of Oncology 24, no. 5 (2004): 1271-1277. https://doi.org/10.3892/ijo.24.5.1271