Structural and functional conservation of the lgl recessive oncogenes (Review)

  • Authors:
    • Kwang-Hyun Baek
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  • Published online on: May 1, 2004     https://doi.org/10.3892/ijo.24.5.1257
  • Pages: 1257-1261
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Abstract

It is becoming gradually evident that the dysregulated cell proliferation and differentiation in neoplasia are associated with aberrant functions of specific genes in the genome. Genes and their cellular functions involved in cell proliferation and differentiation are highly conserved among different species. Therefore, the illustration of evolutionary relationships among gene products in different species can provide structural and functional insights, leading to neoplastic studies in lower animals that can help to understand the mechanisms of neoplastic development in vertebrates including humans. This review introduces the possibility that studies with lethal giant larvae (lgl) tumor suppressor family members can provide a better understanding of their functional roles during tumor development in eukaryotic cells.

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May 2004
Volume 24 Issue 5

Print ISSN: 1019-6439
Online ISSN:1791-2423

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APA
Baek, K. (2004). Structural and functional conservation of the lgl recessive oncogenes (Review). International Journal of Oncology, 24, 1257-1261. https://doi.org/10.3892/ijo.24.5.1257
MLA
Baek, K."Structural and functional conservation of the lgl recessive oncogenes (Review)". International Journal of Oncology 24.5 (2004): 1257-1261.
Chicago
Baek, K."Structural and functional conservation of the lgl recessive oncogenes (Review)". International Journal of Oncology 24, no. 5 (2004): 1257-1261. https://doi.org/10.3892/ijo.24.5.1257