Molecular targeting for malignant gliomas (Review)

  • Authors:
    • Yasuko Kondo
    • Emporia F. Hollingsworth
    • Seiji Kondo
  • View Affiliations

  • Published online on: May 1, 2004     https://doi.org/10.3892/ijo.24.5.1101
  • Pages: 1101-1109
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Abstract

With tendency to invade rapidly in the brain, malignant gliomas are very resistant to conventional therapies including radiation and chemotherapy. Recent advances in genetic and molecular techniques have made it possible to define characteristic molecular profiles of malignant gliomas. Based on the list of the molecules closely related to glioblastoma tissues, we reviewed strategies targeting them. Target molecules extensively studied include EGFR, PTEN, telomerase and signal pathway modulators for Ras/Raf/MAPK and PI3K/Akt/mTOR pathways. Therapies targeting specific molecules may result in killing tumor cells effectively while keeping normal cells intact.

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Journal Cover

May 2004
Volume 24 Issue 5

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Copy and paste a formatted citation
APA
Kondo, Y., Hollingsworth, E.F., & Kondo, S. (2004). Molecular targeting for malignant gliomas (Review). International Journal of Oncology, 24, 1101-1109. https://doi.org/10.3892/ijo.24.5.1101
MLA
Kondo, Y., Hollingsworth, E. F., Kondo, S."Molecular targeting for malignant gliomas (Review)". International Journal of Oncology 24.5 (2004): 1101-1109.
Chicago
Kondo, Y., Hollingsworth, E. F., Kondo, S."Molecular targeting for malignant gliomas (Review)". International Journal of Oncology 24, no. 5 (2004): 1101-1109. https://doi.org/10.3892/ijo.24.5.1101