Alphavirus vectors for cancer gene therapy (Review)

  • Authors:
    • Ryuya Yamanaka
  • View Affiliations

  • Published online on: April 1, 2004     https://doi.org/10.3892/ijo.24.4.919
  • Pages: 919-923
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Abstract

Alphaviruses have several characteristics that make them attractive as gene therapy vectors such as transient and high-level expression of a heterologous gene. Alphavirus vectors, Semliki Forest virus (SFV), Sindbis virus (SIN) and Venezuelan equine encephalitis virus (VEE) have been developed as gene expression vectors. Alphaviruses are positive-strand RNA viruses that can mediate efficient cytoplasmic gene expression in mammalian cells. The alphavirus RNA replication machinery has been engineered for high level heterologous gene expression. Since an RNA virus vector cannot integrate into chromosomal DNA, concerns about cell transformation are reduced. Alphavirus vectors demonstrate promise for the safe tumor-killing and tumor-specific immune responses. Recombinant alphavirus RNA replicons may facilitate gene therapy of cancer.

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April 2004
Volume 24 Issue 4

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Copy and paste a formatted citation
APA
Yamanaka, R. (2004). Alphavirus vectors for cancer gene therapy (Review). International Journal of Oncology, 24, 919-923. https://doi.org/10.3892/ijo.24.4.919
MLA
Yamanaka, R."Alphavirus vectors for cancer gene therapy (Review)". International Journal of Oncology 24.4 (2004): 919-923.
Chicago
Yamanaka, R."Alphavirus vectors for cancer gene therapy (Review)". International Journal of Oncology 24, no. 4 (2004): 919-923. https://doi.org/10.3892/ijo.24.4.919